Sang Won Kang Professor
Life Sciences/Life Sciences
Prof. Sang Won Kang in Department of Life Sciences is a leading scientist in the field of reactive oxygen species-mediated signal transduction. He began to study the ROS signaling in NIH, U.S., with postdoctoral career, as a pioneer in the field. He is particularly interested in the mechanism of ROS function in the signal transduction and furthermore tries to apply the research result to the medical aspects to find a clue for human chronic diseases, such as cancer and vascular diseases. Since he joined the department, he published the important results on the high-impact journals (e.g. Nature, Molecular Cell, etc). He is also actively involved in the proteomics society.
- Science Building C #504
- 02-3277-3352
- Office hours
- 화 9 - 10시, 목 9 - 11시
Research Record
- A small molecule compound that inhibits blue light-induced retinal damage via activation of autophagy Biochemical Pharmacology, 2023, v.211, 115534
- Blood flow patterns switch VEGFR2 activity through differential S-nitrosylation and S-oxidation Cell Reports, 2023, v.42 no.11, 113361
- Conserved miR-370-3p/BMP-7 axis regulates the phenotypic change of human vascular smooth muscle cells Scientific reports, 2023, v.13 no.1, 2404
- Glucose Deprivation Induces Cancer Cell Death through Failure of ROS Regulation International Journal of Molecular Sciences, 2023, v.24 no.15, 11969
- Heat shock protein 60 couples an oxidative stress-responsive p38/MK2 signaling and NF-κB survival machinery in cancer cells Redox Biology, 2022, v.51, 102293
- PI3Kγ stimulates a high molecular weight form of myosin light chain kinase to promote myeloid cell adhesion and tumor inflammation Nature Communications, 2022, v.13 no.1, 1768
- RIP3-Dependent Accumulation of Mitochondrial Superoxide Anions in TNF-α-Induced Necroptosis Molecules and Cells, 2022, v.45 no.4, 193-201
- CHIP and BAP1 Act in Concert to Regulate INO80 Ubiquitination and Stability for DNA Replication MOLECULES AND CELLS, 2021, v.44 no.2, 101-115
- GPx-1-encoded adenoviral vector attenuates dopaminergic impairments induced by methamphetamine in GPx-1 knockout mice through modulation of NF-KB transcription factor FOOD AND CHEMICAL TOXICOLOGY, 2021, v.154, 112313
- Glutathione peroxidase-1 regulates ASK1-dependent apoptosis via interaction with TRAF2 in RIPK3-negative cancer cells EXPERIMENTAL AND MOLECULAR MEDICINE, 2021, v.53 no.6, 1080-1091
- Circulating lipidomic alterations in obese and non-obese subjects with non-alcoholic fatty liver disease ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2020, v.52 no.10, 1603-1614
- Glutathione peroxidase-1 regulates adhesion and metastasis of triple-negative breast cancer cells via FAK signaling REDOX BIOLOGY, 2020, v.29, UNSP 101391
- Peroxidasin is essential for endothelial cell survival and growth signaling by sulfilimine crosslink-dependent matrix assembly FASEB JOURNAL, 2020, v.34 no.8, 10228-10241
- Phosphorylation of OCT4 Serine 236 Inhibits Germ Cell Tumor Growth by Inducing Differentiation CANCERS, 2020, v.12 no.9, 2601
- SEZ6L2 Is an Important Regulator of Drug-Resistant Cells and Tumor Spheroid Cells in Lung Adenocarcinoma BIOMEDICINES, 2020, v.8 no.11, 500
- Absence of Cytosolic 2-Cys Prx Subtypes I and II Exacerbates TNF-alpha-Induced Apoptosis via Different Routes CELL REPORTS, 2019, v.26 no.8, 2194-
- Coxsackievirus and adenovirus receptor mediates the responses of endothelial cells to fluid shear stress EXPERIMENTAL AND MOLECULAR MEDICINE, 2019, v.51, 144
- Gossypol Suppresses Growth of Temozolomide-Resistant Glioblastoma Tumor Spheres BIOMOLECULES, 2019, v.9 no.10, 595
- A rapamycin derivative, biolimus, preferentially activates autophagy in vascular smooth muscle cells SCIENTIFIC REPORTS, 2018, v.8, 16551
- Lipidomic profiling reveals free fatty acid alterations in plasma from patients with atrial fibrillation PLOS ONE, 2018, v.13 no.5
- OCT4 directly regulates sternness and extracellular matrix-related genes in human germ cell tumours BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2018, v.503 no.3, 1980-1986
- Prdx1 (peroxiredoxin 1) deficiency reduces cholesterol efflux via impaired macrophage lipophagic flux AUTOPHAGY, 2018, v.14 no.1, 120-133
- Silencing of peroxiredoxin II by promoter methylation is necessary for the survival and migration of gastric cancer cells EXPERIMENTAL AND MOLECULAR MEDICINE, 2018, v.50
- INO80 haploinsufficiency inhibits colon cancer tumorigenesis via replication stress-induced apoptosis Oncotarget, 2017, v.8 no.70, 115041-115053
- Interaction of tankyrase and peroxiredoxin II is indispensable for the survival of colorectal cancer cells Nature Communications, 2017, v.8 no.1
- Peroxiredoxin I participates in the protection of reactive oxygen species-mediated cellular senescence BMB Reports, 2017, v.50 no.10, 528-533
- Snail reprograms glucose metabolism by repressing phosphofructokinase PFKP allowing cancer cell survival under metabolic stress Nature Communications, 2017, v.8
- Survival of APC-mutant colorectal cancer cells requires interaction between tankyrase and a thiol peroxidase, peroxiredoxin II BMB Reports, 2017, v.50 no.8, 391-392
- A Decoy Peptide Targeted to Protein Phosphatase 1 Attenuates Degradation of SERCA2a in Vascular Smooth Muscle Cells PLOS ONE, 2016, v.11 no.10, e0165569
- Antidepressant indatraline induces autophagy and inhibits restenosis via suppression of mTOR/S6 kinase signaling pathway SCIENTIFIC REPORTS, 2016, v.6
- Discovery of novel peptides targeting pro-atherogenic endothelium in disturbed flow regions-Targeted siRNA delivery to pro-atherogenic endothelium in vivo Scientific Reports, 2016, v.6
- NADPH Oxidase 1 Activity and ROS Generation Are Regulated by Grb2/Cbl-Mediated Proteasomal Degradation of NoxO1 in Colon Cancer Cells CANCER RESEARCH, 2016, v.76 no.4
- Ursodeoxycholic Acid (UDCA) exerts anti-Atherogenic effects by inhibiting RAGE signaling in diabetic atherosclerosis PLoS ONE, 2016, v.11 no.1
- ATM-mediated phosphorylation of the chromatin remodeling enzyme BRG1 modulates DNA double-strand break repair ONCOGENE, 2015, v.34 no.3, 351-361
- Cytosolic Hsp60 orchestrates the survival and inflammatory responses of vascular smooth muscle cells in injured aortic vessels Cardiovascular Research, 2015, v.106 no.3, 498-508
- ROS and energy metabolism in cancer cells: alliance for fast growth Archives of Pharmacal Research, 2015, v.38 no.3
- Vascular Proteomics Reveal Novel Proteins Involved in SMC Phenotypic Change: OLR1 as a SMC Receptor Regulating Proliferation and Inflammatory Response PLOS ONE, 2015, v.10 no.8
- 2-Cys peroxiredoxins: Emerging hubs determining redox dependency of mammalian signaling networks International Journal of Cell Biology, 2014, v. 2014
- Dominant Role of Peroxiredoxin/JNK Axis in Stemness Regulation During Neurogenesis from Embryonic Stem Cells STEM CELLS, 2014, v.32 no.4, 998-1011
- Nuclear and cytoplasmic p53 suppress cell invasion by inhibiting respiratory Complex-I activity via Bcl-2 family proteins ONCOTARGET, 2014, v.5 no.18, 8452-8465
- [학술지논문] Blood flow patterns switch VEGFR2 activity through differential S-nitrosylation and S-oxidation CELL REPORTS, 2023, v.42 no.11 , 1-13
- [학술지논문] Heat shock protein 60 couples an oxidative stress-responsive p38/MK2 signaling and NF-Kappa B survival machinery in cancer cells REDOX BIOLOGY, 2022, v.51 no.102293 , 1-14
- [학술지논문] PI3K gamma stimulates a high molecular weight form of myosin light chain kinase to promote myeloid cell adhesion and tumor inflammation NATURE COMMUNICATIONS, 2022, v.13 no.1 , 1768-1768
- [학술지논문] RIP3-Dependent Accumulation of Mitochondrial Superoxide Anions in TNF-alpha-Induced Necroptosis MOLECULES AND CELLS, 2022, v.45 no.4 , 193-201
- [학술지논문] Glutathione peroxidase-1 regulates adhesion and metastasis of triple-negative breast cancer cells via FAK signaling REDOX BIOLOGY, 2020, v.29 no.0 , 101391-101391
- [학술지논문] Absence of Cytosolic 2-Cys Prx Subtypes I and II Exacerbates TNF-alpha-Induced Apoptosis via Different Routes CELL REPORTS, 2019, v.26 no.8 , 2194-2194
Courses
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2024-1st
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General Biology
- Subject No 20412Class No 04
- 1Year ( 3Credit , 3Hour) Mon 5~5 (POSCO453) , Wed 4~4 (POSCO453)
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Biochemistry Ⅰ
- Subject No 33716Class No 01
- 2Year ( 3Credit , 3Hour) Mon 3~3 (POSCO361) , Wed 2~2 (POSCO361)
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Experiments in Life Sciences Ⅰ
- Subject No 35309Class No 01
- 2Year ( 2Credit , 3Hour) Mon 6~7 (SCI-AA205)
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Experiments in Life Sciences Ⅰ
- Subject No 35309Class No 02
- 2Year ( 2Credit , 3Hour) Tue 6~7 (SCI-AA205)
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Experiments in Life Sciences Ⅰ
- Subject No 35309Class No 03
- 2Year ( 2Credit , 3Hour) Wed 6~7 (SCI-AA205)
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Experiments in Life Sciences Ⅰ
- Subject No 35309Class No 04
- 2Year ( 2Credit , 3Hour) Thu 6~7 (SCI-AA205)
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Experiments in Life Sciences Ⅰ
- Subject No 35309Class No 05
- 2Year ( 2Credit , 3Hour) Fri 6~7 (SCI-AA205)
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Biology of Reactive Oxygen Species Ⅰ
- Subject No G16942Class No 01
- Year ( 3Credit , 3Hour) Tue 3~4 (SCI-C)
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Special Topics in Advanced Biochemistry Ⅰ
- Subject No G16946Class No 01
- Year ( 3Credit , 3Hour) Mon 5~6 (SCI-C)
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2022-2nd
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Biochemistry II
- Subject No 35824Class No 01
- 2Year ( 3Credit , 3Hour) Mon 4~4 (POSCO361) , Thu 5~5 (POSCO361)
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Introduction to Cell Signaling
- Subject No 38212Class No 01
- 3Year ( 3Credit , 3Hour) Tue 5~5 (POSCO361) , Thu 6~6 (POSCO361)
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Research for Life ScienceⅡ
- Subject No G16933Class No 01
- Year ( 3Credit , 3Hour)
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Biology of Reactive Oxygen SpeciesⅡ
- Subject No G16943Class No 01
- Year ( 3Credit , 3Hour) Wed 2~3 (SCI-C)
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2022-1st
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General Biology I
- Subject No 20413Class No 04
- 1Year ( 3Credit , 3Hour) Tue 2~2 (POSCO453) , Fri 3~3 (POSCO453)
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Biochemistry I
- Subject No 33716Class No 01
- 2Year ( 3Credit , 3Hour) Mon 3~3 (POSCO361) , Wed 2~2 (POSCO361)
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Experiments in Life Sciences I
- Subject No 35309Class No 01
- 2Year ( 2Credit , 3Hour) Mon 6~7 (SCI-AA205)
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Experiments in Life Sciences I
- Subject No 35309Class No 02
- 2Year ( 2Credit , 3Hour) Tue 6~7 (SCI-AA205)
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Experiments in Life Sciences I
- Subject No 35309Class No 03
- 2Year ( 2Credit , 3Hour) Wed 6~7 (SCI-AA205)
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Experiments in Life Sciences I
- Subject No 35309Class No 04
- 2Year ( 2Credit , 3Hour) Thu 6~7 (SCI-AA205)
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Experiments in Life Sciences I
- Subject No 35309Class No 05
- 2Year ( 2Credit , 3Hour) Fri 6~7 (SCI-AA205)
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2021-2nd
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Biochemistry II
- Subject No 35824Class No 01
- 2Year ( 3Credit , 3Hour) Mon 4~4 (POSCO451) , Thu 5~5 (POSCO451)
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Introduction to Cell Signaling
- Subject No 38212Class No 01
- 3Year ( 3Credit , 3Hour) Mon 6~6 (POSCO453) , Wed 5~5 (POSCO453)
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Research for Life ScienceⅡ
- Subject No G16933Class No 01
- Year ( 3Credit , 3Hour)
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Biology of Reactive Oxygen SpeciesⅡ
- Subject No G16943Class No 01
- Year ( 3Credit , 3Hour) Wed 2~3 (SCI-C)
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2021-1st
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General Biology I
- Subject No 20413Class No 04
- 1Year ( 3Credit , 3Hour) Mon 2~2 , Thu 3~3
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Biochemistry I
- Subject No 33716Class No 01
- 2Year ( 3Credit , 3Hour) Wed 3~3 (POSCO363) , Fri 2~2 (POSCO363)
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Experiments in Life Sciences I
- Subject No 35309Class No 01
- 2Year ( 2Credit , 3Hour) Mon 6~7
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Experiments in Life Sciences I
- Subject No 35309Class No 02
- 2Year ( 2Credit , 3Hour) Tue 6~7
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Experiments in Life Sciences I
- Subject No 35309Class No 03
- 2Year ( 2Credit , 3Hour) Thu 6~7
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Experiments in Life Sciences I
- Subject No 35309Class No 04
- 2Year ( 2Credit , 3Hour) Fri 6~7
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Experiments in Life Sciences I
- Subject No 35309Class No 05
- 2Year ( 2Credit , 3Hour) Thu 4~5 (SCI-AA205)
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Redox RegulationⅡ
- Subject No G16945Class No 01
- Year ( 3Credit , 3Hour) Thu 5~6 (SCI-C418)
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Bio Technology
- Subject No G16974Class No 01
- Year ( 3Credit , 3Hour) Wed 5~6 (SCI-C)
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Academic Background
YONSEI UNIVERSITY 이학박사(생화학과)