Soo Young Lee Professor
Life Sciences/College of Medicine/Life Sciences
Professor Soo Young Lee received his PhD degree from Korea University, Korea. He conducted postdoctoral research at the Rockefeller University in New York, USA. He is currently Professor at the Department of Life Science, College of Natural Sciences, Ewha Womans University, Korea. His main research topics include inflammation, innate immunity and bone metabolism in inflammation- and aging-related bone disorders. He was a Principal Investigator of National Research Laboratory from 2008 to 2013. He has published more than 80 peer-reviewed articles in reputed internatioanl journals.
- Science Building C #419
- 02-3277-3770
Research Record
- 5-aminosalicylic acid suppresses osteoarthritis through the OSCAR-PPARγ axis Nature Communications, 2024, v.15 no.1, 0
- Octyl gallate has potent anti-inflammasome activity by directly binding to NLRP3 LRR domain Journal of Cellular Physiology, 2024, v.239 no.4, e31196
- RUFY4 deletion prevents pathological bone loss by blocking endo-lysosomal trafficking of osteoclasts Bone Research, 2024, v.12 no.1, 29
- Development of Anti-OSCAR Antibodies for the Treatment of Osteoarthritis Biomedicines, 2023, v.11 no.10, 2844
- Differential Expression Patterns of Toll-like Receptors in COVID-19 Patients FRONTIERS IN BIOSCIENCE-LANDMARK, 2023, v.28 no.11, 307
- IgSF11 deficiency alleviates osteoarthritis in mice by suppressing early subchondral bone changes Experimental and Molecular Medicine, 2023, v.55 no.12, 2576-2585
- BCAT1 promotes osteoclast maturation by regulating branched-chain amino acid metabolism Experimental and Molecular Medicine, 2022, v.54, 825-833
- BCAT1 promotes osteoclast maturation by regulating branched-chain amino acid metabolism Experimental and Molecular Medicine, 2022, v.54 no.6, 825-833
- Pim1 promotes IFN-β production by interacting with IRF3 Experimental and Molecular Medicine, 2022, v.54, 1-12
- Tetraspanin 7 regulates osteoclast function through association with the RANK/αvβ3 integrin complex Journal of Cellular Physiology, 2022, v.237 no.1, 846-855
- Core promoter activity contributes to chromatin-based regulation of internal cryptic promoters NUCLEIC ACIDS RESEARCH, 2021, v.49 no.14, 8097-8109
- Selenoprotein W ensures physiological bone remodeling by preventing hyperactivity of osteoclasts Nature Communications, 2021, v.12 no.1, 2258
- Benzydamine inhibits osteoclast differentiation and bone resorption via down-regulation of interleukin-1β expression Acta Pharmaceutica Sinica B, 2020, v.10 no.3, 462-474
- Cinchonine inhibits osteoclast differentiation by regulating TAK1 and AKT, and promotes osteogenesis Journal of Cellular Physiology, 2020, v.236 no.3, 0
- Deacetylation by SIRT1 promotes the tumor-suppressive activity of HINT1 by enhancing its binding capacity for beta-catenin or MITF in colon cancer and melanoma cells EXPERIMENTAL AND MOLECULAR MEDICINE, 2020, v.52 no.7, 1075-1089
- Early estrogen-induced gene 1 facilitates osteoclast formation through the inhibition of interferon regulatory factor 8 expression FASEB JOURNAL, 2020, v.34 no.9, 12894-12906
- GDNF secreted by pre-osteoclasts induces migration of bone marrow mesenchymal stem cells and stimulates osteogenesis BMB REPORTS, 2020 , 646-651
- Intensive morphometric analysis of enormous alterations in skeletal bone system with micro-CT for AHNAK−/− mice Anatomical Science International, 2020, v.95 no.3, 323-333
- Naa20, the catalytic subunit of NatB complex, contributes to hepatocellular carcinoma by regulating the LKB1-AMPK-mTOR axis EXPERIMENTAL AND MOLECULAR MEDICINE, 2020 , 1831-1844
- Osteoclast-associated receptor blockade prevents articular cartilage destruction via chondrocyte apoptosis regulation Nature Communications, 2020, v.11 no.1, 4343
- Plasma proteomic profiling of young and old mice reveals cadherin-13 prevents age-related bone loss AGING-US, 2020, v.12 no.9, 8652-8668
- Spi-C positively regulates RANKL-mediated osteoclast differentiation and function EXPERIMENTAL AND MOLECULAR MEDICINE, 2020, v.52 no.4, 691-701
- C-Cbl negatively regulates TRAF6-mediated NF-B activation by promoting K48-linked polyubiquitination of TRAF6 CELLULAR & MOLECULAR BIOLOGY LETTERS, 2019, v.24, 29
- Glycogen Synthase Kinase 3β Regulates Antiviral Responses of TLR3 via TRAF2-Src Axis Journal of immunology (Baltimore, Md. : 1950), 2019, v.203 no.11, 2990-2999
- RACK1 interaction with c-Src is essential for osteoclast function Experimental and Molecular Medicine, 2019, v.51 no.7, 86
- Metabolic alterations in the bone tissues of aged osteoporotic mice Scientific Reports, 2018, v.8 no.1
- STAC2 negatively regulates osteoclast formation by targeting the RANK signaling complex CELL DEATH AND DIFFERENTIATION, 2018, v.25 no.8, 1364-1374
- Current Understanding of RANK Signaling in Osteoclast Differentiation and Maturation MOLECULES AND CELLS, 2017, v.40 no.10, 706-713
- Euphorbia factor L1 inhibits osteoclastogenesis by regulating cellular redox status and induces Fas-mediated apoptosis in osteoclast Free Radical Biology and Medicine, 2017, v.112, 191-199
- Reciprocal regulation of TLR2-mediated IFN-β production by SHP2 and Gsk3β Scientific Reports, 2017, v.7 no.1
- Saturated fatty acid determination method using paired ion electrospray ionization mass spectrometry coupled with capillary electrophoresis ANALYTICA CHIMICA ACTA, 2017, v.984, 223-231
- A novel pyrazole derivative protects from ovariectomy-induced osteoporosis through the inhibition of NADPH oxidase Scientific Reports, 2016, v.6
- A novel small-molecule PPI inhibitor targeting integrin alpha(v)beta(3)-osteopontin interface blocks bone resorption in vitro and prevents bone loss in mice BIOMATERIALS, 2016, v.98, 131-142
- Accelerated lactate dehydrogenase activity potentiates osteoclastogenesis via NFATc1 signaling PLoS ONE, 2016, v.11 no.4
- FlexPro MD, a Mixture of Krill Oil, Astaxanthin, and Hyaluronic Acid, Suppresses Lipopolysaccharide-Induced Inflammatory Cytokine Production Through Inhibition of NF-kappa B JOURNAL OF MEDICINAL FOOD, 2016, v.19 no.12, 1196-1203
- Glycogen synthase kinase 3 beta in Toll-like receptor signaling BMB REPORTS, 2016, v.49 no.6, 305-310
- Sirt6 cooperates with Blimp1 to positively regulate osteoclast differentiation Scientific Reports, 2016, v.6
- Sirtuin 3 (SIRT3) maintains bone homeostasis by regulating AMPK-PGC-1β axis in mice Scientific Reports, 2016, v.6
- ADP-ribosylation factor 1 regulates proliferation, migration, and fusion in early stage of osteoclast differentiation International Journal of Molecular Sciences, 2015, v.16 no.12, 29305-29314
- Glycogen synthase kinase 3 beta ubiquitination by TRAF6 regulates TLR3-mediated pro-inflammatory cytokine production NATURE COMMUNICATIONS, 2015, v.6
- NK cell function triggered by multiple activating receptors is negatively regulated by glycogen synthase kinase-3β Cellular Signalling, 2015, v.27 no.9, 1731-1741
- The scaffold protein RACK1 mediates the RANKL-dependent activation of p38 MAPK in osteoclast precursors SCIENCE SIGNALING, 2015, v.8 no.379
- Tight junction protein 1 is regulated by transforming growth factor-beta and contributes to cell motility in NSCLC cells BMB REPORTS, 2015, v.48 no.2, 115-120
- 2-(Trimethylammonium) Ethyl (R)-3-Methoxy-3-oxo-2-Stearamidopropyl Phosphate Suppresses Osteoclast Maturation and Bone Resorption by Targeting Macrophage-Colony Stimulating Factor Signaling MOLECULES AND CELLS, 2014, v.37 no.8, 628-635
- PKC beta Positively Regulates RANKL-Induced Osteoclastogenesis by Inactivating GSK-3 beta MOLECULES AND CELLS, 2014, v.37 no.10, 747-752
- TRP14 Inhibits Osteoclast Differentiation via Its Catalytic Activity MOLECULAR AND CELLULAR BIOLOGY, 2014, v.34 no.18, 3515-3524
- [학술지논문] 5-aminosalicylic acid suppresses osteoarthritis through the OSCAR-PPARγ axis NATURE COMMUNICATIONS, 2024, v.15 no.1 , 1024-1024
- [학술지논문] Octyl gallate has potent anti-inflammasome activity by directly binding to NLRP3 LRR domain JOURNAL OF CELLULAR PHYSIOLOGY, 2024, v.239 no.4 , 1-13
- [학술지논문] RUFY4 deletion prevents pathological bone loss by blocking endo-lysosomal trafficking of osteoclasts BONE RESEARCH, 2024, v.12 no.1 , 1-14
- [학술지논문] Pim1 promotes IFN-β production by interacting with IRF3 EXPERIMENTAL AND MOLECULAR MEDICINE, 2022, v.54 no.0 , 2092-2103
- [학술지논문] Tetraspanin 7 regulates osteoclast function through association with the RANK/alpha v beta 3 integrin complex JOURNAL OF CELLULAR PHYSIOLOGY, 2022, v.237 no.1 , 846-855
- [학술지논문] Core promoter activity contributes to chromatin-based regulation of internal cryptic promoters NUCLEIC ACIDS RESEARCH, 2021, v.49 no.14 , 8097-8109
- [학술지논문] Early estrogen-induced gene 1 facilitates osteoclast formation through the inhibition of interferon regulatory factor 8 expression FASEB JOURNAL, 2020, v.34 no.9 , 12894-12906
- [학술지논문] Osteoclast-associated receptor blockade prevents articular cartilage destruction via chondrocyte apoptosis regulation NATURE COMMUNICATIONS, 2020, v.11 no.1 , 4343-4343
- [학술지논문] Glycogen Synthase Kinase 3 beta Regulates Antiviral Responses of TLR3 via TRAF2-Src Axis JOURNAL OF IMMUNOLOGY, 2019, v.203 no.11 , 2990-2999
- [학술지논문] RACK1 interaction with c-Src is essential for osteoclast function EXPERIMENTAL AND MOLECULAR MEDICINE, 2019, v.51 no.7 , 86-86
Courses
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2023-2nd
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Immunology 강의 계획서 상세보기
- Subject No 20593Class No 01
- 3Year ( 3Credit , 3Hour) Tue 3~3 (SCI-AA) , Thu 2~2 (102)
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Molecular Medical Science 강의 계획서 상세보기
- Subject No 36336Class No 01
- 4Year ( 3Credit , 3Hour) Mon 4~4 (SCI-AA) , Thu 5~5 (102)
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Cellular Signal Transduction
- Subject No G16997Class No 01
- Year ( 3Credit , 3Hour) Fri 2~3 (SCI-C)
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2023-1st
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Introductory Biology 강의 계획서 상세보기
- Subject No 10066Class No 01
- Year ( 3Credit , 3Hour) Mon 3~3 , Thu 4~4
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General Biology 강의 계획서 상세보기
- Subject No 20412Class No 04
- 1Year ( 3Credit , 3Hour) Mon 4~4 (POSCO453) , Thu 5~5 (POSCO453)
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General Biology: Laboratory Work I 강의 계획서 상세보기
- Subject No 33332Class No 01
- 1Year ( 1Credit , 1.5Hour) Mon 6~6 (SCI-AA203)
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General Biology: Laboratory Work I 강의 계획서 상세보기
- Subject No 33332Class No 02
- 1Year ( 1Credit , 1.5Hour) Wed 6~6 (SCI-AA203)
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General Biology: Laboratory Work I 강의 계획서 상세보기
- Subject No 33332Class No 03
- 1Year ( 1Credit , 1.5Hour) Thu 6~6 (SCI-AA203)
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General Biology: Laboratory Work I 강의 계획서 상세보기
- Subject No 33332Class No 04
- 1Year ( 1Credit , 1.5Hour) Fri 6~6 (SCI-AA203)
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Experiments in Life Sciences III 강의 계획서 상세보기
- Subject No 35313Class No 01
- 3Year ( 2Credit , 3Hour) Thu 6~7 (SCI-AA202)
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Experiments in Life Sciences III 강의 계획서 상세보기
- Subject No 35313Class No 02
- 3Year ( 2Credit , 3Hour) Fri 6~7 (SCI-AA202)
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Research for Life ScienceⅠ
- Subject No G16932Class No 01
- Year ( 3Credit , 3Hour)
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Advanced Immunology
- Subject No G16979Class No 01
- Year ( 3Credit , 3Hour) Tue 5~5 (SCI-C) , Tue 7~7 (101)
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2022-2nd
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Immunology
- Subject No 20593Class No 01
- 3Year ( 3Credit , 3Hour) Tue 3~3 (POSCO361) , Thu 2~2 (POSCO361)
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General Biology: Laboratory Work II
- Subject No 33333Class No 01
- 1Year ( 1Credit , 1.5Hour) Mon 6~7 (SCI-AA202)
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General Biology: Laboratory Work II
- Subject No 33333Class No 02
- 1Year ( 1Credit , 1.5Hour) Wed 6~7 (SCI-AA202)
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Molecular Medical Science
- Subject No 36336Class No 01
- 4Year ( 3Credit , 3Hour) Wed 3~3 (SCI-AA) , Fri 2~2 (101)
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Life Science SeminarⅣ
- Subject No G16931Class No 01
- Year ( 3Credit , 3Hour) Thu 3~4 (SCI-C)
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Research for Life ScienceⅡ
- Subject No G16933Class No 01
- Year ( 3Credit , 3Hour)
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Special Topics in Immunology
- Subject No G16953Class No 01
- Year ( 3Credit , 3Hour) Thu 5~6 (SCI-C)
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2022-1st
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General Biology
- Subject No 20412Class No 01
- 1Year ( 3Credit , 3Hour) Mon 4~4 (POSCO453) , Thu 5~5 (POSCO453)
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Experiments in Life Sciences III
- Subject No 35313Class No 01
- 3Year ( 2Credit , 3Hour) Tue 6~7 (SCI-AA202)
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Experiments in Life Sciences III
- Subject No 35313Class No 02
- 3Year ( 2Credit , 3Hour) Fri 6~7 (SCI-AA202)
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Advanced Immunology
- Subject No G16979Class No 01
- Year ( 3Credit , 3Hour) Thu 5~6 (SCI-C-)
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2021-2nd
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Immunology
- Subject No 20593Class No 01
- 3Year ( 3Credit , 3Hour) Tue 3~3 , Thu 2~2
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Special Topics in Immunology
- Subject No G16953Class No 01
- Year ( 3Credit , 3Hour) Thu 5~6 (SCI-C418)
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2021-1st
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Introductory Biology
- Subject No 10066Class No 01
- Year ( 3Credit , 3Hour) Tue 3~3 , Fri 3~3
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General Biology
- Subject No 20412Class No 01
- 1Year ( 3Credit , 3Hour) Mon 3~3 , Wed 2~2
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Experiments in Life Sciences III
- Subject No 35313Class No 01
- 3Year ( 2Credit , 3Hour) Tue 6~7 (SCI-AA205)
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Experiments in Life Sciences III
- Subject No 35313Class No 02
- 3Year ( 2Credit , 3Hour) Thu 6~7 (SCI-AA205)
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Advanced Immunology
- Subject No G16979Class No 01
- Year ( 3Credit , 3Hour) Tue 5~6 (SCI-C-418)
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Academic Background
Korea Univ. 농학박사(농화학과)