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Ewha University

College of Medicine

Soo Young Lee Professor

Life Sciences/College of Medicine/Life Sciences

이수영 프로필 사진
Professor Soo Young Lee received his PhD degree from Korea University, Korea. He conducted postdoctoral research at the Rockefeller University in New York, USA. He is currently Professor at the Department of Life Science, College of Natural Sciences, Ewha Womans University, Korea. His main research topics include inflammation, innate immunity and bone metabolism in inflammation- and aging-related bone disorders. He was a Principal Investigator of National Research Laboratory from 2008 to 2013. He has published more than 80 peer-reviewed articles in reputed internatioanl journals.
Research Record
  • 5-aminosalicylic acid suppresses osteoarthritis through the OSCAR-PPARγ axis Nature Communications, 2024, v.15 no.1, 0
    SCIE Scopus dColl.
  • Octyl gallate has potent anti-inflammasome activity by directly binding to NLRP3 LRR domain Journal of Cellular Physiology, 2024, v.239 no.4, e31196
    SCIE Scopus dColl.
  • RUFY4 deletion prevents pathological bone loss by blocking endo-lysosomal trafficking of osteoclasts Bone Research, 2024, v.12 no.1, 29
    SCIE Scopus dColl.
  • Development of Anti-OSCAR Antibodies for the Treatment of Osteoarthritis Biomedicines, 2023, v.11 no.10, 2844
    SCIE Scopus dColl.
  • Differential Expression Patterns of Toll-like Receptors in COVID-19 Patients FRONTIERS IN BIOSCIENCE-LANDMARK, 2023, v.28 no.11, 307
    SCIE Scopus dColl.
  • IgSF11 deficiency alleviates osteoarthritis in mice by suppressing early subchondral bone changes Experimental and Molecular Medicine, 2023, v.55 no.12, 2576-2585
    SCIE Scopus KCI dColl.
  • BCAT1 promotes osteoclast maturation by regulating branched-chain amino acid metabolism Experimental and Molecular Medicine, 2022, v.54, 825-833
    KCI dColl.
  • BCAT1 promotes osteoclast maturation by regulating branched-chain amino acid metabolism Experimental and Molecular Medicine, 2022, v.54 no.6, 825-833
    SCIE Scopus KCI dColl.
  • Pim1 promotes IFN-β production by interacting with IRF3 Experimental and Molecular Medicine, 2022, v.54, 1-12
    KCI dColl.
  • Tetraspanin 7 regulates osteoclast function through association with the RANK/αvβ3 integrin complex Journal of Cellular Physiology, 2022, v.237 no.1, 846-855
    SCIE Scopus dColl.
  • Core promoter activity contributes to chromatin-based regulation of internal cryptic promoters NUCLEIC ACIDS RESEARCH, 2021, v.49 no.14, 8097-8109
    SCIE Scopus dColl.
  • Selenoprotein W ensures physiological bone remodeling by preventing hyperactivity of osteoclasts Nature Communications, 2021, v.12 no.1, 2258
    SCIE Scopus dColl.
  • Benzydamine inhibits osteoclast differentiation and bone resorption via down-regulation of interleukin-1β expression Acta Pharmaceutica Sinica B, 2020, v.10 no.3, 462-474
    SCIE Scopus dColl.
  • Cinchonine inhibits osteoclast differentiation by regulating TAK1 and AKT, and promotes osteogenesis Journal of Cellular Physiology, 2020, v.236 no.3, 0
    SCIE Scopus dColl.
  • Deacetylation by SIRT1 promotes the tumor-suppressive activity of HINT1 by enhancing its binding capacity for beta-catenin or MITF in colon cancer and melanoma cells EXPERIMENTAL AND MOLECULAR MEDICINE, 2020, v.52 no.7, 1075-1089
    SCIE Scopus KCI dColl.
  • Early estrogen-induced gene 1 facilitates osteoclast formation through the inhibition of interferon regulatory factor 8 expression FASEB JOURNAL, 2020, v.34 no.9, 12894-12906
    SCIE Scopus dColl.
  • GDNF secreted by pre-osteoclasts induces migration of bone marrow mesenchymal stem cells and stimulates osteogenesis BMB REPORTS, 2020 , 646-651
    SCIE Scopus KCI dColl.
  • Intensive morphometric analysis of enormous alterations in skeletal bone system with micro-CT for AHNAK−/− mice Anatomical Science International, 2020, v.95 no.3, 323-333
    SCIE Scopus dColl.
  • Naa20, the catalytic subunit of NatB complex, contributes to hepatocellular carcinoma by regulating the LKB1-AMPK-mTOR axis EXPERIMENTAL AND MOLECULAR MEDICINE, 2020 , 1831-1844
    SCIE Scopus KCI dColl.
  • Osteoclast-associated receptor blockade prevents articular cartilage destruction via chondrocyte apoptosis regulation Nature Communications, 2020, v.11 no.1, 4343
    SCIE Scopus dColl.
  • Plasma proteomic profiling of young and old mice reveals cadherin-13 prevents age-related bone loss AGING-US, 2020, v.12 no.9, 8652-8668
    SCIE Scopus dColl.
  • Spi-C positively regulates RANKL-mediated osteoclast differentiation and function EXPERIMENTAL AND MOLECULAR MEDICINE, 2020, v.52 no.4, 691-701
    SCIE Scopus KCI dColl.
  • C-Cbl negatively regulates TRAF6-mediated NF-B activation by promoting K48-linked polyubiquitination of TRAF6 CELLULAR & MOLECULAR BIOLOGY LETTERS, 2019, v.24, 29
    SCIE Scopus dColl.
  • Glycogen Synthase Kinase 3β Regulates Antiviral Responses of TLR3 via TRAF2-Src Axis Journal of immunology (Baltimore, Md. : 1950), 2019, v.203 no.11, 2990-2999
    Scopus dColl.
  • RACK1 interaction with c-Src is essential for osteoclast function Experimental and Molecular Medicine, 2019, v.51 no.7, 86
    SCIE Scopus KCI dColl.
  • Metabolic alterations in the bone tissues of aged osteoporotic mice Scientific Reports, 2018, v.8 no.1
    SCIE Scopus dColl.
  • STAC2 negatively regulates osteoclast formation by targeting the RANK signaling complex CELL DEATH AND DIFFERENTIATION, 2018, v.25 no.8, 1364-1374
    SCIE Scopus dColl.
  • Current Understanding of RANK Signaling in Osteoclast Differentiation and Maturation MOLECULES AND CELLS, 2017, v.40 no.10, 706-713
    SCIE Scopus KCI dColl.
  • Euphorbia factor L1 inhibits osteoclastogenesis by regulating cellular redox status and induces Fas-mediated apoptosis in osteoclast Free Radical Biology and Medicine, 2017, v.112, 191-199
    SCIE Scopus dColl.
  • Reciprocal regulation of TLR2-mediated IFN-β production by SHP2 and Gsk3β Scientific Reports, 2017, v.7 no.1
    SCIE Scopus dColl.
  • Saturated fatty acid determination method using paired ion electrospray ionization mass spectrometry coupled with capillary electrophoresis ANALYTICA CHIMICA ACTA, 2017, v.984, 223-231
    SCIE Scopus dColl.
  • A novel pyrazole derivative protects from ovariectomy-induced osteoporosis through the inhibition of NADPH oxidase Scientific Reports, 2016, v.6
    SCIE Scopus dColl.
  • A novel small-molecule PPI inhibitor targeting integrin alpha(v)beta(3)-osteopontin interface blocks bone resorption in vitro and prevents bone loss in mice BIOMATERIALS, 2016, v.98, 131-142
    SCIE Scopus dColl.
  • Accelerated lactate dehydrogenase activity potentiates osteoclastogenesis via NFATc1 signaling PLoS ONE, 2016, v.11 no.4
    SCIE Scopus dColl.
  • FlexPro MD, a Mixture of Krill Oil, Astaxanthin, and Hyaluronic Acid, Suppresses Lipopolysaccharide-Induced Inflammatory Cytokine Production Through Inhibition of NF-kappa B JOURNAL OF MEDICINAL FOOD, 2016, v.19 no.12, 1196-1203
    SCIE Scopus KCI dColl.
  • Glycogen synthase kinase 3 beta in Toll-like receptor signaling BMB REPORTS, 2016, v.49 no.6, 305-310
    SCIE Scopus KCI dColl.
  • Sirt6 cooperates with Blimp1 to positively regulate osteoclast differentiation Scientific Reports, 2016, v.6
    SCIE Scopus dColl.
  • Sirtuin 3 (SIRT3) maintains bone homeostasis by regulating AMPK-PGC-1β axis in mice Scientific Reports, 2016, v.6
    SCIE Scopus dColl.
  • ADP-ribosylation factor 1 regulates proliferation, migration, and fusion in early stage of osteoclast differentiation International Journal of Molecular Sciences, 2015, v.16 no.12, 29305-29314
    Scopus dColl.
  • Glycogen synthase kinase 3 beta ubiquitination by TRAF6 regulates TLR3-mediated pro-inflammatory cytokine production NATURE COMMUNICATIONS, 2015, v.6
    SCIE Scopus dColl.
  • NK cell function triggered by multiple activating receptors is negatively regulated by glycogen synthase kinase-3β Cellular Signalling, 2015, v.27 no.9, 1731-1741
    SCIE Scopus dColl.
  • The scaffold protein RACK1 mediates the RANKL-dependent activation of p38 MAPK in osteoclast precursors SCIENCE SIGNALING, 2015, v.8 no.379
    SCIE Scopus dColl.
  • Tight junction protein 1 is regulated by transforming growth factor-beta and contributes to cell motility in NSCLC cells BMB REPORTS, 2015, v.48 no.2, 115-120
    SCIE KCI Scopus dColl.
  • 2-(Trimethylammonium) Ethyl (R)-3-Methoxy-3-oxo-2-Stearamidopropyl Phosphate Suppresses Osteoclast Maturation and Bone Resorption by Targeting Macrophage-Colony Stimulating Factor Signaling MOLECULES AND CELLS, 2014, v.37 no.8, 628-635
    SCIE KCI Scopus dColl.
  • PKC beta Positively Regulates RANKL-Induced Osteoclastogenesis by Inactivating GSK-3 beta MOLECULES AND CELLS, 2014, v.37 no.10, 747-752
    SCIE KCI dColl.
  • TRP14 Inhibits Osteoclast Differentiation via Its Catalytic Activity MOLECULAR AND CELLULAR BIOLOGY, 2014, v.34 no.18, 3515-3524
    SCIE Scopus dColl.
  • [학술지논문] 5-aminosalicylic acid suppresses osteoarthritis through the OSCAR-PPARγ axis NATURE COMMUNICATIONS, 2024, v.15 no.1 , 1024-1024
    SCIE
  • [학술지논문] Octyl gallate has potent anti-inflammasome activity by directly binding to NLRP3 LRR domain JOURNAL OF CELLULAR PHYSIOLOGY, 2024, v.239 no.4 , 1-13
    SCIE
  • [학술지논문] RUFY4 deletion prevents pathological bone loss by blocking endo-lysosomal trafficking of osteoclasts BONE RESEARCH, 2024, v.12 no.1 , 1-14
    SCIE
  • [학술지논문] Pim1 promotes IFN-β production by interacting with IRF3 EXPERIMENTAL AND MOLECULAR MEDICINE, 2022, v.54 no.0 , 2092-2103
    SCI
  • [학술지논문] Tetraspanin 7 regulates osteoclast function through association with the RANK/alpha v beta 3 integrin complex JOURNAL OF CELLULAR PHYSIOLOGY, 2022, v.237 no.1 , 846-855
    SCI
  • [학술지논문] Core promoter activity contributes to chromatin-based regulation of internal cryptic promoters NUCLEIC ACIDS RESEARCH, 2021, v.49 no.14 , 8097-8109
    SCI
  • [학술지논문] Early estrogen-induced gene 1 facilitates osteoclast formation through the inhibition of interferon regulatory factor 8 expression FASEB JOURNAL, 2020, v.34 no.9 , 12894-12906
    SCI
  • [학술지논문] Osteoclast-associated receptor blockade prevents articular cartilage destruction via chondrocyte apoptosis regulation NATURE COMMUNICATIONS, 2020, v.11 no.1 , 4343-4343
    SCI
  • [학술지논문] Glycogen Synthase Kinase 3 beta Regulates Antiviral Responses of TLR3 via TRAF2-Src Axis JOURNAL OF IMMUNOLOGY, 2019, v.203 no.11 , 2990-2999
    SCI
  • [학술지논문] RACK1 interaction with c-Src is essential for osteoclast function EXPERIMENTAL AND MOLECULAR MEDICINE, 2019, v.51 no.7 , 86-86
    SCI
Courses
  • 2023-2nd

  • 2023-1st

  • 2022-2nd

    • Immunology

      • Subject No 20593Class No 01
      • 3Year ( 3Credit , 3Hour) Tue 3~3 (POSCO361) , Thu 2~2 (POSCO361)
    • General Biology: Laboratory Work II

      • Subject No 33333Class No 01
      • 1Year ( 1Credit , 1.5Hour) Mon 6~7 (SCI-AA202)
    • General Biology: Laboratory Work II

      • Subject No 33333Class No 02
      • 1Year ( 1Credit , 1.5Hour) Wed 6~7 (SCI-AA202)
    • Molecular Medical Science

      • Subject No 36336Class No 01
      • 4Year ( 3Credit , 3Hour) Wed 3~3 (SCI-AA) , Fri 2~2 (101)
    • Life Science SeminarⅣ

      • Subject No G16931Class No 01
      • Year ( 3Credit , 3Hour) Thu 3~4 (SCI-C)
    • Research for Life ScienceⅡ

    • Special Topics in Immunology

      • Subject No G16953Class No 01
      • Year ( 3Credit , 3Hour) Thu 5~6 (SCI-C)
  • 2022-1st

    • General Biology

      • Subject No 20412Class No 01
      • 1Year ( 3Credit , 3Hour) Mon 4~4 (POSCO453) , Thu 5~5 (POSCO453)
    • Experiments in Life Sciences III

      • Subject No 35313Class No 01
      • 3Year ( 2Credit , 3Hour) Tue 6~7 (SCI-AA202)
    • Experiments in Life Sciences III

      • Subject No 35313Class No 02
      • 3Year ( 2Credit , 3Hour) Fri 6~7 (SCI-AA202)
    • Advanced Immunology

      • Subject No G16979Class No 01
      • Year ( 3Credit , 3Hour) Thu 5~6 (SCI-C-)
  • 2021-2nd

    • Immunology

      • Subject No 20593Class No 01
      • 3Year ( 3Credit , 3Hour) Tue 3~3 , Thu 2~2
    • Special Topics in Immunology

      • Subject No G16953Class No 01
      • Year ( 3Credit , 3Hour) Thu 5~6 (SCI-C418)
  • 2021-1st

    • Introductory Biology

      • Subject No 10066Class No 01
      • Year ( 3Credit , 3Hour) Tue 3~3 , Fri 3~3
    • General Biology

      • Subject No 20412Class No 01
      • 1Year ( 3Credit , 3Hour) Mon 3~3 , Wed 2~2
    • Experiments in Life Sciences III

      • Subject No 35313Class No 01
      • 3Year ( 2Credit , 3Hour) Tue 6~7 (SCI-AA205)
    • Experiments in Life Sciences III

      • Subject No 35313Class No 02
      • 3Year ( 2Credit , 3Hour) Thu 6~7 (SCI-AA205)
    • Advanced Immunology

      • Subject No G16979Class No 01
      • Year ( 3Credit , 3Hour) Tue 5~6 (SCI-C-418)
Academic Background

Korea Univ. 농학박사(농화학과)