오세관(吳世觀) 교수

의과대학

오세관 프로필 사진
오세관 교수는 의대 분자의과학 소속 교수로 약물남용과 퇴행성뇌질환 연구의 권위자다. 미국 미시시피 주립 의과대에서 신경약리학분야로 박사학위를 받았으며, 약물남용의 기전규명, 치료제 개발, 규제 등에 대한 연구를 진행하고 있다. 2000년부터 응용약물학회 임원으로 활동하고 있으며, 현재까지 총 100여편의 논문을 SCI급 국제학술지에 발표했으며, 10여건의 특허를 출원 등록하고 있다. 저서로는 『신경전달물질과 뇌질환』(신일북스), 『신경과학』(월드사이언스) 등이 있다.
  • 의학관(마곡) 711호
  • 02-6986-6271
  • 면담 가능시간
    • 월10-12시, 수10-12
연구실적
  • Atypical formations of gintonin lysophosphatidic acids as new materials and their beneficial effects on degenerative diseases Journal of Ginseng Research, 2024, v.48 no.1, 1-11
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  • Chrysanthemum morifolium and Its Bioactive Substance Enhanced the Sleep Quality in Rodent Models via Cl- Channel Activation Nutrients, 2023, v.15 no.6
    SCIE Scopus dColl.
  • Derivatives of 3, 4, 5-Trimethoxycinnamic Acid Ameliorate Stress-Induced Anxiety in Mice and Rats Molecular Neurobiology, 2023, v.60 no.5, 2737-2748
    SCIE Scopus dColl.
  • Phytoceramide Alleviates the Carrageenan/Kaolin-Induced Arthritic Symptoms by Modulation of Inflammation Biomolecules and Therapeutics, 2023, v.31 no.5, 536-543
    SCIE Scopus KCI dColl.
  • JC2-11, a benzylideneacetophenone derivative, attenuates inflammasome activation Scientific Reports, 2022, v.12 no.1, 22484
    SCIE Scopus dColl.
  • Neuroprotective effect of Korean Red Ginseng against single prolonged stress-induced memory impairments and inflammation in the rat brain associated with BDNF expression Journal of Ginseng Research, 2022, v.46 no.3, 435-443
    SCIE Scopus KCI dColl.
  • Fumonisin b1-induced toxicity was not exacerbated in glutathione peroxidase-1/catalase double knock out mice Biomolecules and Therapeutics, 2021, v.29 no.1, 52-57
    SCIE Scopus KCI dColl.
  • Gintonin regulates inflammation in human IL-1 beta-stimulated fibroblast-like synoviocytes and carrageenan/kaolin-induced arthritis in rats through LPAR2 JOURNAL OF GINSENG RESEARCH, 2021, v.45 no.5, 575-582
    SCIE Scopus KCI dColl.
  • Inhibitory activity of gintonin on inflammation in human IL-1 beta-stimulated fibroblast-like synoviocytes and collagen-induced arthritis in mice JOURNAL OF GINSENG RESEARCH, 2021, v.45 no.4, 510-518
    SCIE Scopus KCI dColl.
  • Benzylideneacetophenone Derivative Alleviates Arthritic Symptoms via Modulation of the MAPK Signaling Pathway MOLECULES, 2020, v.25 no.15, 3319
    SCIE Scopus dColl.
  • Fangchinoline Has an Anti-Arthritic Effect in Two Animal Models and in IL-1 beta-Stimulated Human FLS Cells BIOMOLECULES & THERAPEUTICS, 2020, v.28 no.5, 414-422
    SCIE Scopus KCI dColl.
  • Korean Red Ginseng prevents posttraumatic stress disorder-triggered depression-like behaviors in rats via activation of the serotonergic system JOURNAL OF GINSENG RESEARCH, 2020, v.44 no.4, 644-654
    SCIE Scopus KCI dColl.
  • A double-blind, randomized, placebo-controlled crossover clinical study of the effects of alpha-s1 casein hydrolysate on sleep disturbance Nutrients, 2019, v.11 no.7, 1466
    SCIE Scopus dColl.
  • Alleviation of Atopic Dermatitis Lesions by a Benzylideneacetophenone Derivative via the MAPK Signaling Pathway INFLAMMATION, 2019, v.42 no.3, 1093-1102
    SCIE Scopus dColl.
  • Effects of aromatic ring-substituted phenethylamines on the release of dopamine and serotonin Forensic Toxicology, 2019, v.37 no.1, 104-112
    SCIE Scopus dColl.
  • Inhibition of Carrageenan/Kaolin-Induced Arthritis in Rats and of Inflammatory Cytokine Expressions in Human IL-1-Stimulated Fibroblast-like Synoviocytes by a Benzylideneacetophenone Derivative INFLAMMATION, 2019, v.42 no.3, 928-936
    SCIE Scopus dColl.
  • Internalization and Transportation of Endothelial Cell Surface K(Ca)2.3 and K(Ca)3.1 in Normal Pregnancy and Preeclampsia OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2019, v.2019, 5820839
    SCIE Scopus dColl.
  • Morphine Dependence is Attenuated by Treatment of 3,4,5-Trimethoxy Cinnamic Acid in Mice and Rats NEUROCHEMICAL RESEARCH, 2019, v.44 no.4, 874-883
    SCIE Scopus dColl.
  • Administration of Alpha(s1)-Casein Hydrolysate Increases Sleep and Modulates GABA(A) Receptor Subunit Expression BIOMOLECULES & THERAPEUTICS, 2018, v.26 no.3, 268-273
    SCIE Scopus KCI dColl.
  • Cocaine- and Amphetamine-Regulated Transcript (CART) Peptide Plays Critical Role in Psychostimulant-Induced Depression BIOMOLECULES & THERAPEUTICS, 2018, v.26 no.5, 425-431
    SCIE Scopus KCI dColl.
  • Korean Red Ginseng mitigates spinal demyelination in a model of acute multiple sclerosis by downregulating p38 mitogen-activated protein kinase and nuclear factor-kappa B signaling pathways JOURNAL OF GINSENG RESEARCH, 2018, v.42 no.4, 436-446
    SCIE Scopus KCI dColl.
  • Multi-Target Protective Effects of Gintonin in 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Mediated Model of Parkinson's Disease via Lysophosphatidic Acid Receptors FRONTIERS IN PHARMACOLOGY, 2018, v.9
    SCIE Scopus dColl.
  • Multitarget effects of Korean Red Ginseng in animal model of Parkinson's disease: antiapoptosis, antioxidant, antiinflammation, and maintenance of blood-brain barrier integrity JOURNAL OF GINSENG RESEARCH, 2018, v.42 no.3, 379-388
    SCIE Scopus KCI dColl.
  • Sleep-Aids Derived from Natural Products BIOMOLECULES & THERAPEUTICS, 2018, v.26 no.4, 343-349
    SCIE Scopus KCI dColl.
  • A benzylideneacetophenone derivative induces apoptosis of radiation-resistant human breast cancer cells via oxidative stress Biomolecules and Therapeutics, 2017, v.25 no.4, 404-410
    SCIE Scopus KCI dColl.
  • BPA-toxicity via superoxide anion overload and a deficit in β-catenin signaling in human bone mesenchymal stem cells Environmental Toxicology, 2017, v.32 no.1, 344-352
    SCIE Scopus dColl.
  • Chronic stress-induced dendritic reorganization and abundance of synaptosomal PKA-dependent CP-AMPA receptor in the basolateral amygdala in a mouse model of depression Biochemical and Biophysical Research Communications, 2017, v.486 no.3, 671-678
    SCIE Scopus dColl.
  • Concanavalin A Induces Cortical Neuron Apoptosis by Causing ROS Accumulation and Tyrosine Kinase Activation Neurochemical Research, 2017, v.42 no.12, 1-11
    SCIE Scopus dColl.
  • Inhibition of Ceramide Decreased the Expression of ATP-Binding Cassette Transporter G5/8 mRNA in an Animal Model of Cholesterol Gallstone DIGESTIVE DISEASES, 2017, v.35 no.5, 439-443
    SCIE Scopus dColl.
  • Practical Synthesis of Chalcone Derivatives and Their Biological Activities MOLECULES, 2017, v.22 no.11
    SCIE Scopus dColl.
  • Ajoene restored behavioral patterns and liver glutathione level in morphine treated C57BL6 mice Archives of Pharmacal Research, 2016, 28 Oct 2016, 1-6
    SCIE Scopus KCI dColl.
  • Anti-tumor activity of benzylideneacetophenone derivatives via proteasomal inhibition in prostate cancer cells Pharmazie, 2016, v.71 no.5, 274-279
    SCIE Scopus dColl.
  • Hepatoprotective effect of licorice, the root of Glycyrrhiza uralensis Fischer, in alcohol-induced fatty liver disease BMC Complementary and Alternative Medicine, 2016, 22 JAN 2016
    SCIE Scopus dColl.
  • Inhibition of p38 pathway-dependent MPTP-induced dopaminergic neurodegeneration in estrogen receptor alpha knockout mice Hormones and Behavior, 2016, v.80, 19-29
    SCIE Scopus dColl.
  • KCa3.1 upregulation preserves endothelium-dependent vasorelaxation during aging and oxidative stress Aging Cell, 2016, 30 June 2016
    SCIE Scopus dColl.
  • Modulation of NMDA Receptor Subunits Expression by Concanavalin A Neurochemical Research, 2016, 2 APR 2016, 1-12
    SCIE Scopus dColl.
  • Morphine dependence is attenuated by red ginseng extract and ginsenosides Rh2, Rg3, and compound K JOURNAL OF GINSENG RESEARCH, 2016, v.40 no.4, 445-452
    SCIE Scopus KCI dColl.
  • 3,4,5-Trimethoxycinnamin acid ameliorates restraint stress-induced anxiety and depression NEUROSCIENCE LETTERS, 2015, v.585, 54-59
    SCIE Scopus dColl.
  • Administration of red ginseng ameliorates memory decline in aged mice Journal of Ginseng Research, 2015, v.39 no.3, 250-256
    SCIE KCI Scopus dColl.
  • Altering sphingolipid composition with aging induces contractile dysfunction of gastric smooth muscle via K(Ca)1.1 upregulation AGING CELL, 2015, v.14 no.6, 982-994
    Scopus dColl.
  • Anti-inflammatory activities of licorice extract and its active compounds, glycyrrhizic acid, liquiritin and liquiritigenin, in BV2 cells and mice liver Molecules, 2015, v.20 no.7, 13041-13054
    SCIE Scopus dColl.
  • Bergenin decreases the morphine-induced physical dependence via antioxidative activity in mice Archives of Pharmacal Research, 2015, v.38 no.6, 1248-1254
    Scopus dColl.
  • Estrogen receptor-mediated resveratrol actions on blood-brain barrier of ovariectomized mice NEUROBIOLOGY OF AGING, 2015, v.36 no.2, 993-1006
    SCIE Scopus dColl.
  • Korean Red Ginseng and Ginsenoside-Rb1/-Rg1 Alleviate Experimental Autoimmune Encephalomyelitis by Suppressing Th1 and Th17 Cells and Upregulating Regulatory T Cells Molecular Neurobiology, 2015, 2015
    SCIE Scopus dColl.
  • Benzylideneacetophenone derivatives attenuate IFN-gamma-induced IP-10/CXCL10 production in orbital fibroblasts of patients with thyroid-associated ophthalmopathy through STAT-1 inhibition EXPERIMENTAL AND MOLECULAR MEDICINE, 2014, v.46
    SCIE KCI Scopus dColl.
  • Echinacea purpurea root extract enhances the adipocyte differentiation of 3T3-L1 cells ARCHIVES OF PHARMACAL RESEARCH, 2014, v.37 no.6, 803-812
    SCIE KCI Scopus dColl.
  • Ginsenoside compound K inhibits angiogenesis via regulation of sphingosine kinase-1 in human umbilical vein endothelial cells ARCHIVES OF PHARMACAL RESEARCH, 2014, v.37 no.9, 1183-1192
    SCIE KCI Scopus dColl.
  • Immune Enhancing Effects of Echinacea purpurea Root Extract by Reducing Regulatory T Cell Number and Function NATURAL PRODUCT COMMUNICATIONS, 2014, v.9 no.4, 511-514
    SCIE Scopus dColl.
강의
  • 2024-2학기

    • 분자세포생물학Ⅱ 강의 계획서 상세보기

      • 학수번호 34357분반 01
      • 2학년 ( 3학점 , 3시간) 수 2~3 (종D)
      • 전공필수 전공필수/의예2 및 컴퓨터의학 연계전공 이수자만 수강가능
    • 신경교세포생물학

      • 학수번호 G15820분반 01
      • 학년 ( 3학점 , 3시간) 화 3~4
  • 2024-1학기

    • 노화및노인의학

      • 학수번호 G14772분반 01
      • 학년 ( 3학점 , 3시간) 목 7~8
    • 노화및노인의학

      • 학수번호 G15690분반 01
      • 학년 ( 3학점 , 3시간) 목 7~8
    • 신경화학

      • 학수번호 G15755분반 01
      • 학년 ( 3학점 , 3시간) 목 3~4
    • 의학의이해Ⅰ

      • 학수번호 G17672분반 01
      • 학년 ( 3학점 , 3시간) 목 5~6
  • 2023-2학기

    • 분자세포생물학Ⅱ 강의 계획서 상세보기

      • 학수번호 34357분반 01
      • 2학년 ( 3학점 , 3시간) 수 2~3 (종D)
      • 전공필수 전공필수/의예2 및 컴퓨터의학 연계전공 이수자만 수강가능
    • 신경과학의주제별연구

      • 학수번호 G15027분반 01
      • 학년 ( 3학점 , 3시간) 화 3~4
    • 신경과학의주제별연구

      • 학수번호 G15818분반 01
      • 학년 ( 3학점 , 3시간) 화 3~4
  • 2023-1학기

    • 노화및노인의학

      • 학수번호 G14772분반 01
      • 학년 ( 3학점 , 3시간) 목 7~8
    • 노화및노인의학

      • 학수번호 G15690분반 01
      • 학년 ( 3학점 , 3시간) 목 7~8
    • 의학의이해Ⅰ

      • 학수번호 G17672분반 01
      • 학년 ( 3학점 , 3시간) 목 5~6
    • 의학의이해I

      • 학수번호 G18435분반 01
      • 학년 ( 3학점 , 3시간) 목 5~6
  • 2022-2학기

    • 분자세포생물학Ⅱ

      • 학수번호 34357분반 01
      • 2학년 ( 3학점 , 3시간) 수 2~3 (종D)
      • 전공필수 전공필수/의예2/타전공생 수강불가
  • 2022-1학기

    • 노화및노인의학

      • 학수번호 G14772분반 01
      • 학년 ( 3학점 , 3시간) 목 7~8
    • 신경화학 강의 계획서 상세보기

      • 학수번호 G14844분반 01
      • 학년 ( 3학점 , 3시간) 목 2~3
    • 노화및노인의학

      • 학수번호 G15690분반 01
      • 학년 ( 3학점 , 3시간) 목 7~8
    • 신경화학 강의 계획서 상세보기

      • 학수번호 G15755분반 01
      • 학년 ( 3학점 , 3시간) 목 2~3
    • 의학의이해Ⅰ

      • 학수번호 G17672분반 01
      • 학년 ( 3학점 , 3시간) 목 5~6
  • 2021-2학기

    • 분자세포생물학Ⅱ

      • 학수번호 34357분반 01
      • 2학년 ( 3학점 , 3시간) 수 2~3 (종D)
      • 전공필수 전공필수/의예2
    • 신경과학의주제별연구

      • 학수번호 G15818분반 01
      • 학년 ( 3학점 , 3시간) 화 2~3
  • 2021-1학기

    • 노화및노인의학

      • 학수번호 G14772분반 01
      • 학년 ( 3학점 , 3시간) 목 7~8
    • 노화및노인의학

      • 학수번호 G15690분반 01
      • 학년 ( 3학점 , 3시간) 목 7~8
    • 지질신경과학 강의 계획서 상세보기

      • 학수번호 G15756분반 01
      • 학년 ( 3학점 , 3시간) 목 2~3
    • 의학의이해Ⅰ

      • 학수번호 G17672분반 01
      • 학년 ( 3학점 , 3시간) 목 5~6
학력

University of Mississippi Ph.D.(약리및독물학)