김희선 교수는 의과대학 분자의과학교실 소속 교수로 분자신경생물학 분야의 전문가이다. 서울대학교 약학대학에서 학사/석사/박사학위를 받았으며, 한국생명공학연구원, 미국 테네시의과대학, 하버드의과대학에서 research fellow 및 instructor로 근무한 후 2000년부터 이화여자대학교에 재직중이다. 신경염증 및 파킨슨병 관련연구를 수행하고 있고 현재까지 100편 이상의 논문을 SCI급 국제학술지에 발표했다. 현재 한국응용약물학회 부회장으로 활동하고 있고 대한퇴행성신경질환학회 학술이사 및 한국연구재단 의약학단 전문위원을 역임하였다.
Administration of Gas6 attenuates lung fibrosis via inhibition of the epithelial-mesenchymal transition and fibroblast activationCell Biology and Toxicology, 2024, v.40 no.1, 20
Anti-inflammatory and antioxidant mechanisms of coniferaldehyde in lipopolysaccharide-induced neuroinflammation: Involvement of AMPK/Nrf2 and TAK1/MAPK/NF-κB signaling pathwaysEuropean Journal of Pharmacology, 2024, v.979, 176850
Creatine supplementation with exercise reduces α-synuclein oligomerization and necroptosis in Parkinson's disease mouse modelJournal of Nutritional Biochemistry, 2024, v.126, 109586
Astrocytic Nrf2 Mediates the Neuroprotective and Anti-Inflammatory Effects of Nootkatone in an MPTP-Induced Parkinson’s Disease Mouse ModelAntioxidants, 2023, v.12 no.11, 1999
Necrosulfonamide exerts neuroprotective effect by inhibiting necroptosis, neuroinflammation, and α-synuclein oligomerization in a subacute MPTP mouse model of Parkinson’s diseaseScientific Reports, 2023, v.13 no.1, 8783
Suppression of neuroinflammation and α-synuclein oligomerization by rotarod walking exercise in subacute MPTP model of Parkinson's diseaseNeurochemistry International, 2023, v.165, 105519
Anti-Inflammatory and Neuroprotective Mechanisms of GTS-21, an α7 Nicotinic Acetylcholine Receptor Agonist, in Neuroinflammation and Parkinson’s Disease Mouse ModelsInternational Journal of Molecular Sciences, 2022, v.23 no.8, 4420
Neurogenic effects of rotarod walking exercise in subventricular zone, subgranular zone, and substantia nigra in MPTP-induced Parkinson’s disease miceScientific Reports, 2022, v.12 no.1, 10544
Apoptosis inhibitor of macrophage (AIM) contributes to IL-10-induced anti-inflammatory response through inhibition of inflammasome activationCell Death and Disease, 2021 , 19
NQO1 mediates the anti-inflammatory effects of nootkatone in lipopolysaccharide-induced neuroinflammation by modulating the AMPK signaling pathwayFree Radical Biology and Medicine, 2021, v.164, 354-368
Papaverine Exerts Neuroprotective Effect by Inhibiting NLRP3 Inflammasome Activation in an MPTP-Induced Microglial Priming Mouse Model Challenged with LPSBIOMOLECULES & THERAPEUTICS, 2021, v.29 no.2, 295-302
Protective role of ABCA1 in ischemic preconditioning is mediated by downregulation of miR-33-5p and miR-135-5pSCIENTIFIC REPORTS, 2021, v.11 no.1, 12511
Estrogen deficiency is associated with brain iron deposition via upregulation of hepcidin expression in aged female miceNEUROBIOLOGY OF AGING, 2020, v.96, 33-42
Papaverine inhibits α-synuclein aggregation by modulating neuroinflammation and matrix metalloproteinase-3 expression in the subacute MPTP/P mouse model of Parkinson's diseaseBiomedicine and Pharmacotherapy, 2020, v.130, 110576
Exercise exerts an anxiolytic effect against repeated restraint stress through 5-HT2A-mediated suppression of the adenosine A(2A) receptor in the basolateral amygdalaPSYCHONEUROENDOCRINOLOGY, 2019, v.108, 182-189
Gas6 Prevents Epithelial-Mesenchymal Transition in Alveolar Epithelial Cells via Production of PGE(2), PGD(2) and Their ReceptorsCELLS, 2019, v.8 no.7, 643
The phosphodiesterase 10 inhibitor papaverine exerts anti-inflammatory and neuroprotective effects via the PKA signaling pathway in neuroinflammation and Parkinson's disease mouse modelsJOURNAL OF NEUROINFLAMMATION, 2019, v.16 no.1, 246
Treadmill exercise restores high fat diet-induced disturbance of hippocampal neurogenesis through β2-adrenergic receptor-dependent induction of thioredoxin-1 and brain-derived neurotrophic factorBrain Research, 2019, v.1707, 154-163
Anti-inflammatory and anti-oxidant mechanisms of an MMP-8 inhibitor in lipoteichoic acid-stimulated rat primary astrocytes: involvement of NF-B, Nrf2, and PPAR- signaling pathwaysJOURNAL OF NEUROINFLAMMATION, 2018, v.15, 326
Apoptotic cells trigger the ABCA1/STAT6 pathway leading to PPAR- expression and activation in macrophagesJOURNAL OF LEUKOCYTE BIOLOGY, 2018, v.103 no.5, 885-895
Sulforaphane rescues amyloid-beta peptide-mediated decrease in MerTK expression through its anti-inflammatory effect in human THP-1 macrophagesJOURNAL OF NEUROINFLAMMATION, 2018, v.15
Anti-inflammatory mechanism of galangin in lipopolysaccharide-stimulated microglia: Critical role of PPAR-γ signaling pathwayBiochemical Pharmacology, 2017, v.144, 120-131
Regulation of neuroinflammation by matrix metalloproteinase-8 inhibitor derivatives in activated microglia and astrocytesONCOTARGET, 2017, v.8 no.45, 78677-78690
Resveratrol Ameliorates Tau Hyperphosphorylation at Ser396 Site and Oxidative Damage in Rat Hippocampal Slices Exposed to Vanadate: Implication of ERK1/2 and GSK-3β Signaling CascadesJournal of Agricultural and Food Chemistry, 2017, v.65 no.44, 9626-9634
Suppression of Lipopolysaccharide-Induced Neuroinflammation by Morin via MAPK, PI3K/Akt, and PKA/HO-1 Signaling Pathway ModulationJOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2017, v.65 no.2, 373-382
Suppression of neuroinflammation by matrix metalloproteinase-8 inhibitor in aged normal and LRRK2 G2019S Parkinson's disease model mice challenged with lipopolysaccharideBiochemical and Biophysical Research Communications, 2017, v.493 no.2, 879-886
Exogenous C2 ceramide suppresses matrix metalloproteinase gene expression by inhibiting ROS production and MAPK signaling pathways in PMA-stimulated human astroglioma cellsInternational Journal of Molecular Sciences, 2016, v.17 no.4
Liver X receptor and STAT1 cooperate downstream of Gas6/Mer to induce anti-inflammatory arginase 2 expression in macrophagesSCIENTIFIC REPORTS, 2016, v.6
Protopanaxatriol ginsenoside Rh1 upregulates phase II antioxidant enzyme gene expression in rat primary astrocytes: Involvement of MAP kinases and NRF2/ARE signalingBiomolecules and Therapeutics, 2016, v.24 no.1, 33-39
S100A9 Exacerbates the A beta 1-42-mediated Innate Immunity in Human THP-1 MonocytesCNS & NEUROLOGICAL DISORDERS-DRUG TARGETS, 2016, v.15 no.8, 910-917
Short-chain C2 ceramide induces heme oxygenase-1 expression by upregulating AMPK and MAPK signaling pathways in rat primary astrocytesNeurochemistry International, 2016, 9 FEB 2016
β-Lapachone increases phase II antioxidant enzyme expression via NQO1-AMPK/PI3K-Nrf2/ARE signaling in rat primary astrocytesFree Radical Biology and Medicine, 2016, v.97, 168-178
Anti-inflammatory Mechanism of Ginseng Saponin Metabolite Rh3 in Lipopolysaccharide-Stimulated Microglia: Critical Role of 5′-Adenosine Monophosphate-Activated Protein Kinase Signaling PathwayJournal of Agricultural and Food Chemistry, 2015, v.63 no.13, 3472-3480
Mer signaling increases the abundance of the transcription factor LXR to promote the resolution of acute sterile inflammationSCIENCE SIGNALING, 2015, v.8 no.365
The cross - Violence, Compassion and the Resurrection: A feminist reading of the cross for Korean Christian womenMadang: Journal of Contextual Theology, 2015, v.0 no.23, 107-128
Visceral adipose tissue inflammation is associated with age-related brain changes and ischemic brain damage in aged miceBrain, Behavior, and Immunity, 2015, 14 Jul 2015
β-Lapachone suppresses neuroinflammation by modulating the expression of cytokines and matrix metalloproteinases in activated microgliaJournal of Neuroinflammation, 2015, v.12 no.1
Anti-Inflammatory Effects of alpha-Galactosylceramide Analogs in Activated Microglia : Involvement of the p38 MAPK Signaling PathwayPLOS ONE, 2014, v.9 no.2, Article ID e87030
Arctigenin increases hemeoxygenase-1 gene expression by modulating PI3K/AKT signaling pathway in rat primary astrocytesBiomolecules and Therapeutics, 2014, v.22 no.6, 497-502
Comparison of the Effects of Matrix Metalloproteinase Inhibitors on TNF-alpha Release from Activated Microglia and TNF-alpha Converting Enzyme ActivityBIOMOLECULES & THERAPEUTICS, 2014, v.22 no.5, 414-419
Matrix Metalloproteinase-8 Plays a Pivotal Role in Neuroinflammation by Modulating TNF-alpha ActivationJOURNAL OF IMMUNOLOGY, 2014, v.193 no.5, 2384-2393
Regulation of hemeoxygenase-1 gene expression by Nrf2 and c-Jun in tertiary butylhydroquinone-stimulated rat primary astrocytesBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2014, v.447 no.4, 672-677
The anti-inflammatory role of tissue inhibitor of metalloproteinase-2 in lipopolysaccharide-stimulated microgliaJournal of Neuroinflammation, 2014, v.11
[학술지논문] Administration of Gas6 attenuates lung fibrosis via inhibition of the epithelial-mesenchymal transition and fibroblast activation
CELL BIOLOGY AND TOXICOLOGY, 2024, v.40
no.1
, 20-20
SCIE
[학술지논문] Creatine supplementation with exercise reduces α-synuclein oligomerization and necroptosis in Parkinson’s disease mouse model
JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 2024, v.126
no.1
, 109586-109586
SCIE
[학술지논문] Astrocytic Nrf2 Mediates the Neuroprotective and Anti-Inflammatory Effects of Nootkatone in an MPTP-Induced Parkinson's Disease Mouse Model
ANTIOXIDANTS, 2023, v.12
no.11
, 1999-1999
SCIE
[학술지논문] Necrosulfonamide exerts neuroprotective effect by inhibiting necroptosis, neuroinflammation, and alpha-synuclein oligomerization in a subacute MPTP mouse model of Parkinson's disease
SCIENTIFIC REPORTS, 2023, v.13
no.8783
, 1-15
SCIE
[학술지논문] RIPK1 Regulates Microglial Activation in Lipopolysaccharide-Induced Neuroinflammation and MPTP-Induced Parkinson's Disease Mouse Models
CELLS, 2023, v.12
no.3
, 1-20
SCIE
[학술지논문] Suppression of neuroinflammation and ?-synuclein oligomerization by rotarod walking exercise in subacute MPTP model of Parkinson?s disease
NEUROCHEMISTRY INTERNATIONAL, 2023, v.165
no.105519
, 1-13
SCIE
[학술지논문] Anti-Inflammatory and Neuroprotective Mechanisms of GTS-21, an alpha 7 Nicotinic Acetylcholine Receptor Agonist, in Neuroinflammation and Parkinson's Disease Mouse Models
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, v.23
no.8
, 4420-4420
SCIE
[학술지논문] Neurogenic effects of rotarod walking exercise in subventricular zone, subgranular zone, and substantia nigra in MPTP-induced Parkinson's disease mice
SCIENTIFIC REPORTS, 2022, v.12
no.1
, 10544-10544
SCI
[학술지논문] Apoptosis inhibitor of macrophage (AIM) contributes to IL-10-induced anti-inflammatory response through inhibition of inflammasome activation
CELL DEATH & DISEASE, 2021, v.12
no.1
, 19-19
SCIE
[학술지논문] Matrix Metalloproteinase-8 Inhibitor Ameliorates Inflammatory Responses and Behavioral Deficits in LRRK2 G2019S Parkinson's Disease Model Mice
BIOMOLECULES & THERAPEUTICS, 2021, v.29
no.5
, 483-491
SCIE
[학술지논문] NQO1 mediates the anti-inflammatory effects of nootkatone in lipopolysaccharide-induced neuroinflammation by modulating the AMPK signaling pathway
FREE RADICAL BIOLOGY AND MEDICINE, 2021, v.164
no.0
, 354-368
SCI
[학술지논문] Papaverine Exerts Neuroprotective Effect by Inhibiting NLRP3 Inflammasome Activation in an MPTP-Induced Microglial Priming Mouse Model Challenged with LPS
BIOMOLECULES & THERAPEUTICS, 2021, v.29
no.2
, 295-302
SCIE
[학술지논문] Protective role of ABCA1 in ischemic preconditioning is mediated by downregulation of miR-33-5p and miR-135-5p
SCIENTIFIC REPORTS, 2021, v.11
no.1
, 12511-12511
SCI
[학술지논문] The Potent PDE10A Inhibitor MP-10 (PF-2545920) Suppresses Microglial Activation in LPS-Induced Neuroinflammation and MPTP-Induced Parkinson's Disease Mouse Models
JOURNAL OF NEUROIMMUNE PHARMACOLOGY, 2021, v.16
no.2
, 470-482
SCIE
[학술지논문] Estrogen deficiency is associated with brain iron deposition via upregulation of hepcidin expression in aged female mice
NEUROBIOLOGY OF AGING, 2020, v.96
no.0
, 33-42
SCI
[학술지논문] Papaverine inhibits alpha-synuclein aggregation by modulating neuroinflammation and matrix metalloproteinase-3 expression in the subacute MPTP/P mouse model of Parkinson's disease
BIOMEDICINE & PHARMACOTHERAPY, 2020, v.130
no.0
, 110576-110576
SCI
[학술지논문] Anti-inflammatory and antioxidant mechanisms of urolithin B in activated microglia
PHYTOMEDICINE, 2019, v.55
no.0
, 50-57
SCIE
[학술지논문] Exercise Prevents Memory Consolidation Defects Via Enhancing Prolactin Responsiveness of CA1 Neurons in Mice Under Chronic Stress
MOLECULAR NEUROBIOLOGY, 2019, v.56
no.9
, 6609-6625
SCI
[학술지논문] Exercise exerts an anxiolytic effect against repeated restraint stress through 5-HT2A-mediated suppression of the adenosine A(2A) receptor in the basolateral amygdala
PSYCHONEUROENDOCRINOLOGY, 2019, v.108
no.0
, 182-189
SCI
[학술지논문] Gas6 Prevents Epithelial-Mesenchymal Transition in Alveolar Epithelial Cells via Production of PGE(2), PGD(2) and Their Receptors
CELLS, 2019, v.8
no.7
, 643-643
SCIE
[학술지논문] Neuroprotective effect of β-lapachone in MPTP-induced Parkinson’s disease mouse model: involvement of astroglial p-AMPK/Nrf2/HO-1 signaling pathways
BIOMOLECULES & THERAPEUTICS, 2019, v.27
no.2
, 178-184
SCIE
[학술지논문] The phosphodiesterase 10 inhibitor papaverine exerts anti-inflammatory and neuroprotective effects via the PKA signaling pathway in neuroinflammation and Parkinson's disease mouse models
JOURNAL OF NEUROINFLAMMATION, 2019, v.16
no.1
, 246-246
SCIE
[학술지논문] Treadmill exercise restores high fat diet-induced disturbance of hippocampal neurogenesis through beta 2-adrenergic receptor-dependent induction of thioredoxin-1 and brain-derived neurotrophic factor
BRAIN RESEARCH, 2019, v.1707
no.0
, 154-163
SCI
[학술발표] Astrocytic Nrf2 mediates the neuroprotective and anti-inflammatory effects of nootkatone in Parkinson’s disease model mice한국응용약물학회 춘계학술대회, 대한민국, 여수, 2023-04-06
Proceedings of the convention of the Korean Society for Applied Pharmacology, 2023, 118-118
[학술발표] Motor skill learning training reduces α-synuclein oligomerization and neuroinflammation in subacute MPTP mouse model of Parkinson’s diseaseThe 15th Annual Meeting of the Korean Society for Neurodegenerative disease, 대한민국, 서울, 2023-09-16
대한퇴행성신경질환학회 학술대회 논문집, 2023, 74-74
[학술발표] Necrosulfonamide has neuroprotective effect by inhibiting necroptosis, neuroinflammation, and α-synuclein oligomerization in Parkinson’s disease mouse modelProceedings of the convention of the Korean Society for Applied Pharmacology, 대한민국, 서울, 2023-10-06
한국응용약물학회 학술대회 논문집, 2023, 101-101
[학술발표] The role of RIPK1 as a regulator of microglial activation in LPS-induced neuroinflamamtion한국응용약물학회 춘계학술대회, 대한민국, 여수, 2023-04-06
Proceedings of the convention of the Korean Society for Applied Pharmacology, 2023, 117-117
[학술발표] The role of RIPK1 as a regulator of microglial activation in neuroinflamamtion and Parkinson’s disease mouse modelsThe 15th Annual Meeting of the Korean Society for Neurodegenerative disease, 대한민국, 서울, 2023-09-16
대한퇴행성신경질환학회 학술대회 논문집, 2023, 70-70
[학술발표] Anti-inflammatory and neuroprotective mechanisms of a selective α7 nicotinic acetylcholine receptor agonist in neuroinflammation and Parkinson’s disease mouse modelsThe 25th Annual Meeting of the Korean Society for Brain and Neural Science, 대한민국, 인천, 2022-05-19
Inspiring the Future through Neuroscience, 2022, 30-30
[학술발표] Neuroprotective and anti-inflammatory effect of nootkatone in MPTP-induced Parkinson’s disease mouse model.한국응용약물학회 추계학술대회, 대한민국, 서울, 2022-10-14
Proceedings of the convention of the Korean Society for Applied Pharmacology, 2022, 401-401
[학술발표] Rotarod walking exercise exerts neurogenic effects in MPTP mouse model of Parkinson’s diseaseThe 25th Annual Meeting of the Korean Society for Brain and Neural Science, 대한민국, 인천, 2022-05-20
Inspiring the Future through Neuroscience, 2022, 45-45
[학술발표] Suppression of α-synuclein oligomerization and neuroinflammation by the rotarod walking exercise in a subacute MPTP mouse model of Parkinson’s disease한국응용약물학회 추계학술대회, 대한민국, 서울, 2022-10-14
Proceedings of the convention of the Korean Society for Applied Pharmacology, 2022, 439-439
[학술발표] Anti-inflammatory mechanism of α7 nicotinic acetylcholine receptor agonist in LPS-induced neuroinflammation한국응용약물학회 추계학술대회, 대한민국, 서울, 2021-10-15
Proceedings of the convention of the Korean Society for Applied Pharmacology, 2021, 357-357
[학술발표] Rotarod walking exercise restores the disturbance of adult neurogenesis in hippocampus and substantia nigra regions through facilitating AMPK/BDNF pathway한국응용약물학회 추계학술대회, 대한민국, 서울, 2021-10-15
Proceedings of the convention of the Korean Society for Applied Pharmacology, 2021, 414-414
[학술발표] The antioxidant enzyme NQO1 plays a critical role in the anti-inflammatory effect of nootkatone in LPS-induced neuroinflammationThe 24th Annual Meeting of the Korean Society for Brain and Neural Science, 대한민국, 서울, 2021-05-20
Future Challenges in Brain Science, 2021, 127-127
[학술발표] The neuroprotective and anti-inflammatory effects of papaverine in MPTP-induced microglial priming mouse model challenged with LPS. The 24th Annual Meeting of the Korean Society for Brain and Neural Science, 대한민국, 서울, 2021-05-20
Future Challenges in Brain Science, 2021, 126-126
[학술발표] Anti-inflammatory and antioxidant effects of the sesquiterpenoid compound nootkatone in LPS-induced neuroinflammation한국뇌신경과학회 국제학술대회, 대한민국, 서울, 2020-11-16
The 23rd Annual Meeting of the Korean Society for Brain and Neural Science, 2020, 97-97
[학술발표] Anti-inflammatory and neuroprotective effects of the phosphodiesterase 10 inhibitor in neuroinflammation and Parkinson’s disease mouse models한국응용약물학회 추계학술대회, 대한민국, 서울, 2020-10-16
Proceedings of the convention of the Korean Society for Applied Pharmacology, 2020, 265-265
[학술발표] Inhibition of α-synuclein aggregation by papaverine in the subacute MPTP/P mouse model of Parkinson’s disease.한국뇌신경과학회 국제학술대회, 대한민국, 서울, 2020-11-16
The 23rd Annual Meeting of the Korean Society for Brain and Neural Science, 2020, 119-119
[학술발표] Anti-inflammatory and neuroprotecttive effects of PDE-10 inhibitor in neuroinflammation and Parkinson’s disease animal models. The 10th IBRO World Congress of Neuroscience, 대한민국, 대구, 2019-09-24
IBRO2019, 2019, 179-179
[학술발표] Anxiolytic effect of exercise against repeated restraint stress through 5-HT2A-mediated suppression of the adenosine A2A receptor in the basolateral amygdalaThe 10th IBRO World Congress of Neuroscience, 대한민국, 대구, 2019-09-24
IBRO2019, 2019, 179-179
[학술발표] Neuroprotecttive effects of natural naphtoquinone compound in parkinson’s disease mouse model: involvement of astroglial Nrf2/HO-1 signaling pathwayThe 27th Annual Meeting & International Symposium of KSAP, 대한민국, 서울, 2019-10-11
Proceedings of the convention of the Korean Society for Applied Pharmacology, 2019, 336-336
[학술발표] β-Lapachone exerts neuroprotective effects in MPTP-injected mice by upregulating the p-AMPK/Nrf2/HO-1 signaling pathways in astrocytesThe 10th IBRO World Congress of Neuroscience., 대한민국, 대구, 2019-09-23
IBRO2019, 2019, 143-143