심현보 교수는 생명과학전공 소속 교수로 항체공학의 전문가이다. 서울대학교 화학과에서 학사 및 석사학위를 받고, 미국 텍사스 A&M 대학교에서 생유기화학 전공으로 박사학위를 받았다. 미국 스크립스 연구소와 XOMA사에서 항체 개발연구를 진행하였으며 현재 다양한 항체공학기술과 항체치료제 개발 연구를 진행하고 있다. 인간항체라이브러리 기술은 다수의 산업체 기술이전과 산학협력연구 등으로 활용되고 있다.
A novel bispecific antibody dual-targeting approach for enhanced neutralization against fast-evolving SARS-CoV-2 variantsFRONTIERS IN IMMUNOLOGY, 2023, v.14, 1271508
A Fully‐Human Antibody Specifically Targeting a Membrane‐Bound Fragment of CADM1 Potentiates the T Cell‐Mediated Death of Human Small‐Cell Lung Cancer CellsInternational Journal of Molecular Sciences, 2022, v.23 no.13, 6895
A Novel Synthetic Antibody Library with Complementarity-Determining Region Diversities Designed for an Improved Amplification ProfileInternational Journal of Molecular Sciences, 2022, v.23 no.11, 6255
An internalizing antibody targeting of cell surface GRP94 effectively suppresses tumor angiogenesis of colorectal cancerBiomedicine and Pharmacotherapy, 2022, v.150, 113051
Development and Characterization of Phage-Display-Derived Novel Human Monoclonal Antibodies against the Receptor Binding Domain of SARS-CoV-2Biomedicines, 2022, v.10 no.12, 3274
A Human Antibody That Binds to the Sixth Ig-Like Domain of VCAM-1 Blocks Lung Cancer Cell Migration In VitroINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2017, v.18 no.3
Ratio of Autoantibodies of Tumor Suppressor AIMP2 and Its Oncogenic Variant Is Associated with Clinical Outcome in Lung CancerJOURNAL OF CANCER, 2017, v.8 no.8, 1347-1354
Development of a sandwich enzyme-linked immunosorbent assay for the detection of CD44v3 using exon v3-and v6-specific monoclonal antibody pairsJOURNAL OF IMMUNOLOGICAL METHODS, 2016, v.436, 22-28
Affinity Maturation of Monoclonal Antibody 1E11 by Targeted Randomization in CDR3 Regions Optimizes Therapeutic Antibody Targeting of HER2-Positive Gastric CancerPLOS ONE, 2015, v.10 no.7
Generation of a human antibody that inhibits TSPAN8-mediated invasion of metastatic colorectal cancer cellsBiochemical and Biophysical Research Communications, 2015, v.468 no.4, 774-780
Selective inhibition of the function of tyrosine-phosphorylated STAT3 with a phosphorylation site-specific intrabodyPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2014, v.111 no.17, 6269-6274