SANG-HYUK LEE Professor
Life Sciences/Life Sciences/Bio-Information Science
Prof. Sanghyuk Lee is a leading scientist in the field of bioinformatics and cancer genomics. He served as the director of Korean Bioinformation Center, the president of the Korean Society for Bioinformatics and Systems Biology, the committee member of National Science and Technology Commission. He published more than 70 scientific papers in renowned journals including Nature Genetics, Science, Genome Research, Nucleic Acids Research, Bioinformatics, etc. Currently he serves as the director of Ewha Research Center for Systems Biology and an international advisory board member of the international nucleotide sequence database collaboration (INSDC).
- Dean, The College of Natural Sciences
- Science Building C #512
- 02-3277-2888
- Office hours
- 목10-12시, 금10-12시
Research Record
- DRSPRING: Graph convolutional network (GCN)-Based drug synergy prediction utilizing drug-induced gene expression profile Computers in Biology and Medicine, 2024, v.174, 108436
- Conserved miR-370-3p/BMP-7 axis regulates the phenotypic change of human vascular smooth muscle cells Scientific reports, 2023, v.13 no.1, 2404
- Symmetry Breaking of Human Pluripotent Stem Cells (hPSCs) in Micropattern Generates a Polarized Spinal Cord-Like Organoid (pSCO) with Dorsoventral Organization Advanced Science, 2023, v.10 no.20, 2301787
- Comprehensive Analysis of Alternative Splicing in Gastric Cancer Identifies Epithelial-Mesenchymal Transition Subtypes Associated with Survival Cancer Research, 2022, v.82 no.4, 543-555
- Direct cell-to-cell transfer in stressed tumor microenvironment aggravates tumorigenic or metastatic potential in pancreatic cancer npj Genomic Medicine, 2022, v.7 no.1, 63
- Fluid Shear Stress Regulates the Landscape of microRNAs in Endothelial Cell-Derived Small Extracellular Vesicles and Modulates the Function of Endothelial Cells INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, v.23 no.3, 1314
- Heat shock protein 60 couples an oxidative stress-responsive p38/MK2 signaling and NF-Kappa B survival machinery in cancer cells Redox Biology, 2022, v.51, 102293
- Mice transgenic for human CTLA4-CD28 fusion gene show proliferation and transformation of ATLL-like and AITL-like T cells ONCOIMMUNOLOGY, 2022, v.11 no.1, 2015170
- Nox4-IGF2 Axis Promotes Differentiation of Embryoid Body Cells Into Derivatives of the Three Embryonic Germ Layers Stem Cell Reviews and Reports, 2022, v.18 no.3, 1181-1192
- Production of human spinal-cord organoids recapitulating neural-tube morphogenesis Nature Biomedical Engineering, 2022, v.6 no.4, 435-448
- Elucidating molecular mechanisms of acquired resistance to BRAF inhibitors in melanoma using a microfluidic device and deep sequencing Genomics and Informatics, 2021, v.19 no.1, e2
- FCN3 functions as a tumor suppressor of lung adenocarcinoma through induction of endoplasmic reticulum stress Cell Death and Disease, 2021, v.12 no.4, 407
- Genome-scale CRISPR screening identifies cell cycle and protein ubiquitination processes as druggable targets for erlotinib-resistant lung cancer Molecular Oncology, 2021, v.15 no.2, 487-502
- Proprotein convertase subtilisin/kexin Type 9 is required for Ahnak-mediated metastasis of melanoma into lung epithelial cells NEOPLASIA, 2021, v.23 no.9, 993-1001
- iCSDB: An integrated database of CRISPR screens Nucleic Acids Research, 2021 , D956-D961
- Angioimmunoblastic T-cell lymphoma-like lymphadenopathy in mice transgenic for human RHOA with p.Gly17Val mutation ONCOIMMUNOLOGY, 2020, v.9 no.1, 0
- Bioinformatics services for analyzing massive genomic datasets Genomics and Informatics, 2020, v.18 no.1, e8
- Characterization of TNNC1 as a Novel Tumor Suppressor of Lung Adenocarcinoma Molecules and cells, 2020, v.43 no.7, 619-631
- ChimerDB 4.0: an updated and expanded database of fusion genes Nucleic acids research, 2020, v.48 no.D1, D817-D824
- Earlier-Phased Cancer Immunity Cycle Strongly Influences Cancer Immunity in Operable Never-Smoker Lung Adenocarcinoma iScience, 2020, v.23 no.8, 101386
- Genome-scale screening of deubiquitinase subfamily identifies USP3 as a stabilizer of Cdc25A regulating cell cycle in cancer CELL DEATH AND DIFFERENTIATION, 2020, v.27 no.11, 3004-3020
- Glutathione peroxidase-1 regulates adhesion and metastasis of triple-negative breast cancer cells via FAK signaling REDOX BIOLOGY, 2020, v.29, UNSP 101391
- NuA3 HAT antagonizes the Rpd3S and Rpd3L HDACs to optimize mRNA and lncRNA expression dynamics NUCLEIC ACIDS RESEARCH, 2020 , 10753-10767
- PDX models of human lung squamous cell carcinoma: Consideration of factors in preclinical and co-clinical applications Journal of Translational Medicine, 2020, v.18 no.1, 307
- Validity of patient-derived xenograft mouse models for lung cancer based on exome sequencing data Genomics and Informatics, 2020, v.18 no.1, e3
- An Integrative Data Mining and Omics-Based Translational Model for the Identification and Validation of Oncogenic Biomarkers of Pancreatic Cancer CANCERS, 2019, v.11 no.2, 155
- CaPSSA: visual evaluation of cancer biomarker genes for patient stratification and survival analysis using mutation and expression data BIOINFORMATICS, 2019, v.35 no.24, 5341-5343
- FusionScan: accurate prediction of fusion genes from RNA-Seq data Genomics & Informatics, 2019, v.17 no.3, e26
- Fusionscan: Accurate prediction of fusion genes from RNA-seq data Genomics and Informatics, 2019, v.17 no.3, e26
- Human cytomegalovirus induces and exploits Roquin to counteract the IRF1-mediated antiviral state PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019, v.116 no.37, 18619-18628
- Identification of tumor suppressor miRNAs by integrative miRNA and mRNA sequencing of matched tumor-normal samples in lung adenocarcinoma MOLECULAR ONCOLOGY, 2019, v.13 no.6, 1356-1368
- Proteogenomic Characterization of Human Early-Onset Gastric Cancer Cancer Cell, 2019, v.35 no.1, 111-1.24E12
- An integrated clinical and genomic information system for cancer precision medicine BMC MEDICAL GENOMICS, 2018, v.11
- GEMiCCL: mining genotype and expression data of cancer cell lines with elaborate visualization DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION, 2018, v.
- Integrative Profiling of Alternative Splicing Induced by U2AF1 S34F Mutation in Lung Adenocarcinoma Reveals a Mechanistic Link to Mitotic Stress MOLECULES AND CELLS, 2018, v.41 no.8, 733-741
- Isolation and Functional Examination of the Long Non-Coding RNA Redrum Molecules and cells, 2018, v.41 no.2, 134-139
- Rpd3L HDAC links H3K4me3 to transcriptional repression memory NUCLEIC ACIDS RESEARCH, 2018, v.46 no.16, 8261-8274
- Silencing of peroxiredoxin II by promoter methylation is necessary for the survival and migration of gastric cancer cells Experimental & molecular medicine, 2018, v.50 no.2, e443
- Studying cancer immunotherapy using patient-derived xenografts (PDXs) in humanized mice EXPERIMENTAL AND MOLECULAR MEDICINE, 2018, v.50, 99
- Characterization of developmental defects in the forebrain resulting from hyperactivated mTOR signaling by integrative analysis of transcriptomic and proteomic data SCIENTIFIC REPORTS, 2017, v.7
- ChimerDB 3.0: an enhanced database for fusion genes from cancer transcriptome and literature data mining NUCLEIC ACIDS RESEARCH, 2017, v.45 no.D1, D784-D789
- Integrative analysis of DNA methylation and mRNA expression during differentiation of umbilical cord blood derived mononuclear cells to endothelial cells Gene, 2017, v.635, 48-60
- Interaction of tankyrase and peroxiredoxin II is indispensable for the survival of colorectal cancer cells Nature Communications, 2017, v.8 no.1
- Korean Variant Archive (KOVA): A reference database of genetic variations in the Korean population Scientific Reports, 2017, v.7 no.1
- Frequent CTLA4-CD28 gene fusion in diverse types of T-cell lymphoma HAEMATOLOGICA, 2016, v.101 no.6, 757-763
- MONGKIE: an integrated tool for network analysis and visualization for multi-omics data BIOLOGY DIRECT, 2016, v.11
- Programming of Plant Leaf Senescence with Temporal and Inter-Organellar Coordination of Transcriptome in Arabidopsis PLANT PHYSIOLOGY, 2016, v.171 no.1, 452-467
- Rapid emergence and mechanisms of resistance by U87 glioblastoma cells to doxorubicin in an in vitro tumor microfluidic ecology PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2016, v.113 no.50, 14283-14288
- A highly recurrent novel missense mutation in CD28 among angioimmunoblastic T-cell lymphoma patients HAEMATOLOGICA, 2015, v.100 no.12, E505-E507
- Characterization of SLC22A18 as a tumor suppressor and novel biomarker in colorectal cancer Oncotarget, 2015, v.6 no.28, 25368-25380
- Cytosolic Hsp60 orchestrates the survival and inflammatory responses of vascular smooth muscle cells in injured aortic vessels Cardiovascular Research, 2015, v.106 no.3, 498-508
- EMSAR: estimation of transcript abundance from RNA-seq data by mappability-based segmentation and reclustering BMC BIOINFORMATICS, 2015, v.16
- Obesity Resistance and Enhanced Insulin Sensitivity in Ahnak(-/-) Mice Fed a High Fat Diet Are Related to Impaired Adipogenesis and Increased Energy Expenditure PLOS ONE, 2015, v.10 no.10
- VAMP2-NRG1 Fusion Gene is a Novel Oncogenic Driver of Non-Small-Cell Lung Adenocarcinoma JOURNAL OF THORACIC ONCOLOGY, 2015, v.10 no.7, 1107-1111
- VAMP2-NRG1 fusion gene is a novel oncogenic driver of non-small cell lung adenocarcinoma CANCER RESEARCH, 2015, v.75
- miRseqViewer: multi-panel visualization of sequence, structure and expression for analysis of microRNA sequencing data BIOINFORMATICS, 2015, v.31 no.4, 596-598
- 2-Cys peroxiredoxins: Emerging hubs determining redox dependency of mammalian signaling networks International Journal of Cell Biology, 2014, v. 2014
- A recurrent inactivating mutation in RHOA GTPase in angioimmunoblastic T cell lymphoma Nature Genetics, 2014, v.46 no.4, 371-375
- Compact variant-rich customized sequence database and a fast and sensitive database search for efficient proteogenomic analyses Proteomics, 2014, v.14 no.23-24, 2742-2749
- GEPdb: a database for investigating the ternary association of genotype, gene expression and phenotype BIOINFORMATICS, 2014, v.30 no.17, 2540-2542
- GsGator: An integrated web platform for cross-species gene set analysis BMC Bioinformatics, 2014, v.15 no.1
- IncRNAtor: a comprehensive resource for functional investigation of long non-coding RNAs BIOINFORMATICS, 2014, v.30 no.17, 2480-2485
- Positive feedback loop between Sox2 and Sox6 inhibits neuronal differentiation in the developing central nervous system PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2014, v.111 no.7, 2794-2799
- [학술지논문] Conserved miR-370-3p/BMP-7 axis regulates the phenotypic change of human vascular smooth muscle cells SCIENTIFIC REPORTS, 2023, v.13 no.2404 , 1-14
- [학술지논문] Symmetry Breaking of Human Pluripotent Stem Cells (hPSCs) in Micropattern Generates a Polarized Spinal Cord-Like Organoid (pSCO) with Dorsoventral Organization ADVANCED SCIENCE, 2023, v.10 no.2301787 , 1-18
- [학술지논문] A database of 5305 healthy Korean individuals reveals genetic and clinical implications for an East Asian population EXPERIMENTAL AND MOLECULAR MEDICINE, 2022, v.54 no.11 , 1862-1871
- [학술지논문] Comprehensive Analysis of Alternative Splicing in Gastric Cancer Identifies Epithelial-Mesenchymal Transition Subtypes Associated with Survival CANCER RESEARCH, 2022, v.82 no.4 , 543-555
- [학술지논문] Fluid Shear Stress Regulates the Landscape of microRNAs in Endothelial Cell-Derived Small Extracellular Vesicles and Modulates the Function of Endothelial Cells INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, v.23 no.3 , 1314-1314
- [학술지논문] Heat shock protein 60 couples an oxidative stress-responsive p38/MK2 signaling and NF-Kappa B survival machinery in cancer cells REDOX BIOLOGY, 2022, v.51 no.102293 , 1-14
- [학술지논문] Mice transgenic for human CTLA4-CD28 fusion gene show proliferation and transformation of ATLL-like and AITL-like T cells ONCOIMMUNOLOGY, 2022, v.11 no.1 , 2015170-2015170
- [학술지논문] Nox4-IGF2 Axis Promotes Differentiation of Embryoid Body Cells Into Derivatives of the Three Embryonic Germ Layers STEM CELL REVIEWS AND REPORTS, 2022, v.18 no.3 , 1181-1192
- [학술지논문] Production of human spinal-cord organoids recapitulating neural-tube morphogenesis NATURE BIOMEDICAL ENGINEERING, 2022, v.6 no.4 , 435-+
- [학술지논문] Elucidating molecular mechanisms of acquired resistance to BRAF inhibitors in melanoma using a microfluidic device and deep sequencing Genomics and Informatics, 2021, v.19 no.1 , 2-2
- [학술지논문] FCN3 functions as a tumor suppressor of lung adenocarcinoma through induction of endoplasmic reticulum stress CELL DEATH & DISEASE, 2021, v.12 no.4 , 407-407
- [학술지논문] Genome-scale CRISPR screening identifies cell cycle and protein ubiquitination processes as druggable targets for erlotinib-resistant lung cancer Molecular Oncology, 2021, v.15 no.2 , 487-502
- [학술지논문] Proprotein convertase subtilisin/kexin Type 9 is required for Ahnak-mediated metastasis of melanoma into lung epithelial cells NEOPLASIA, 2021, v.23 no.9 , 993-1001
- [학술지논문] iCSDB: an integrated database of CRISPR screens NUCLEIC ACIDS RESEARCH, 2021, v.49 no.D1 , 956-961
- [학술지논문] Angioimmunoblastic T-cell lymphoma-like lymphadenopathy in mice transgenic for human RHOA with p.Gly17Val mutation ONCOIMMUNOLOGY, 2020, v.9 no.1 , 1746553-1746553
- [학술지논문] Bioinformatics services for analyzing massive genomic datasets Genomics and Informatics, 2020, v.18 no.1 , 1-10
- [학술지논문] Characterization of TNNC1 as a Novel Tumor Suppressor of Lung Adenocarcinoma MOLECULES AND CELLS, 2020, v.43 no.7 , 619-631
- [학술지논문] ChimerDB 4.0: an updated and expanded database of fusion genes NUCLEIC ACIDS RESEARCH, 2020, v.48 no.D1 , 817-824
- [학술지논문] Earlier-Phased Cancer Immunity Cycle Strongly Influences Cancer Immunity in Operable Never-Smoker Lung Adenocarcinoma iScience, 2020, v.23 no.8 , 1-16
- [학술지논문] Genome-scale screening of deubiquitinase subfamily identifies USP3 as a stabilizer of Cdc25A regulating cell cycle in cancer CELL DEATH AND DIFFERENTIATION, 2020, v.27 no.11 , 3004-3020
- [학술지논문] Glutathione peroxidase-1 regulates adhesion and metastasis of triple-negative breast cancer cells via FAK signaling REDOX BIOLOGY, 2020, v.29 no.0 , 101391-101391
- [학술지논문] NuA3 HAT antagonizes the Rpd3S and Rpd3L HDACs to optimize mRNA and lncRNA expression dynamics NUCLEIC ACIDS RESEARCH, 2020, v.48 no.19 , 10753-10767
- [학술지논문] PDX models of human lung squamous cell carcinoma: consideration of factors in preclinical and co-clinical applications JOURNAL OF TRANSLATIONAL MEDICINE, 2020, v.18 no.1 , 1-13
- [학술지논문] Validity of patient-derived xenograft mouse models for lung cancer based on exome sequencing data Genomics and Informatics, 2020, v.18 no.1 , 1-8
- [학술지논문] An Integrative Data Mining and Omics-Based Translational Model for the Identification and Validation of Oncogenic Biomarkers of Pancreatic Cancer CANCERS, 2019, v.11 no.2 , 1-19
- [학술지논문] CaPSSA: visual evaluation of cancer biomarker genes for patient stratification and survival analysis using mutation and expression data BIOINFORMATICS, 2019, v.35 no.24 , 5341-5343
- [학술지논문] FusionScan: accurate prediction of fusion genes from RNA-Seq data Genomics & Informatics, 2019, v.17 no.3 , e26-e26
- [학술지논문] Human cytomegalovirus induces and exploits Roquin to counteract the IRF1-mediated antiviral state PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019, v.116 no.37 , 18619-18628
- [학술지논문] Identification of tumor suppressor miRNAs by integrative miRNA and mRNA sequencing of matched tumor-normal samples in lung adenocarcinoma Molecular Oncology, 2019, v.13 no.6 , 1356-1368
- [학술지논문] Proteogenomic Characterization of Human Early-Onset Gastric Cancer CANCER CELL, 2019, v.35 no.1 , 111-111
Courses
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2024-2nd
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Genomics and Bioinformatics
- Subject No 37119Class No 01
- 3Year ( 3Credit , 3Hour) Mon 6~6 (SCI-AA) , Wed 5~5 (102)
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2024-1st
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General Biology Ⅰ
- Subject No 20413Class No 02
- 1Year ( 3Credit , 3Hour) Tue 4~4 (POSCO453) , Fri 5~5 (POSCO453)
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Computational Medicine; Translating Models to Medicine
- Subject No 38920Class No 01
- Year ( 3Credit , 3Hour) Mon 3~4
- Major Requisite
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Bioinformatics Analysis with Programming
- Subject No G16987Class No 01
- Year ( 3Credit , 3Hour) Wed 5~6 (SCI-C515)
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-
2023-2nd
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Genomics and Bioinformatics 강의 계획서 상세보기
- Subject No 37119Class No 01
- 3Year ( 3Credit , 3Hour) Wed 3~3 (POSCO452) , Fri 2~2 (POSCO452)
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Genome Informatics
- Subject No G17016Class No 01
- Year ( 3Credit , 3Hour) Wed 4~5 (SCI-C515)
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2023-1st
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General Biology I 강의 계획서 상세보기
- Subject No 20413Class No 05
- 1Year ( 3Credit , 3Hour) Tue 2~2 (POSCO365) , Fri 3~3 (POSCO365)
-
Advanced Experiments in Life Sciences Capstone Design I 강의 계획서 상세보기
- Subject No 35829Class No 01
- 4Year ( 2Credit , 3Hour) Tue 1~1 , Thu 1~1
-
Colloquium of Life Science Research 강의 계획서 상세보기
- Subject No 36337Class No 01
- 3Year ( 3Credit , 3Hour) Mon 6~6 (SCI-AA) , Wed 5~5 (101)
-
Computational Medicine; Translating Models to Medicine 강의 계획서 상세보기
- Subject No 38920Class No 01
- Year ( 3Credit , 3Hour) Mon 3~4
- Major Requisite
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Special Topics in BioinformaticsⅠ
- Subject No G16960Class No 01
- Year ( 3Credit , 3Hour) Fri 4~5 (SCI-C-515)
- Class Hour Changed
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2022-2nd
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Genomics and Bioinformatics
- Subject No 37119Class No 01
- 3Year ( 3Credit , 3Hour) Tue 4~4 (POSCO452) , Fri 5~5 (POSCO452)
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Internship for Bioscience II
- Subject No 38219Class No 01
- 4Year ( 1Credit
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Human Genome Sequence Data Analysis
- Subject No G17226Class No 01
- Year ( 3Credit , 3Hour) Fri 2~3 (SCI-C515)
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2022-1st
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General Biology I
- Subject No 20413Class No 05
- 1Year ( 3Credit , 3Hour) Tue 4~4 (POSCO365) , Fri 5~5 (POSCO365)
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Advanced Experiments in Life Sciences Capstone Design I
- Subject No 35829Class No 01
- 4Year ( 2Credit , 3Hour) Tue 1~1 (SCI-AA203) , Thu 1~1 (SCI-AA203)
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Computational Medicine; Translating Models to Medicine
- Subject No 38920Class No 01
- Year ( 3Credit , 3Hour) Mon 3~4
- Major Requisite
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Research for Life ScienceⅠ
- Subject No G16932Class No 01
- Year ( 3Credit , 3Hour)
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Introduction to Bioinformatics
- Subject No G16986Class No 01
- Year ( 3Credit , 3Hour) Tue 2~3 (SCI-C515)
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2021-2nd
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Genomics and Bioinformatics
- Subject No 37119Class No 01
- 3Year ( 3Credit , 3Hour) Wed 6~6 , Fri 4~4
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Internship for Bioscience II
- Subject No 38219Class No 01
- 4Year ( 1Credit
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Research for Life ScienceⅣ
- Subject No G16935Class No 01
- Year ( 3Credit , 3Hour)
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Integrative Biology SeminarⅡ
- Subject No G16967Class No 01
- Year ( 3Credit , 3Hour) Wed 2~3 (SCI-C-515)
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2021-1st
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Introductory Biology
- Subject No 10066Class No 01
- Year ( 3Credit , 3Hour) Tue 3~3 , Fri 3~3
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General Biology I
- Subject No 20413Class No 05
- 1Year ( 3Credit , 3Hour) Tue 2~2 , Fri 3~3
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Experiments in Life Sciences I
- Subject No 35309Class No 01
- 2Year ( 2Credit , 3Hour) Mon 6~7
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Experiments in Life Sciences I
- Subject No 35309Class No 02
- 2Year ( 2Credit , 3Hour) Tue 6~7
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Experiments in Life Sciences I
- Subject No 35309Class No 03
- 2Year ( 2Credit , 3Hour) Thu 6~7
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Experiments in Life Sciences I
- Subject No 35309Class No 04
- 2Year ( 2Credit , 3Hour) Fri 6~7
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Experiments in Life Sciences I
- Subject No 35309Class No 05
- 2Year ( 2Credit , 3Hour) Thu 4~5 (SCI-AA205)
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Advanced Experiments in Life Sciences Capstone Design I
- Subject No 35829Class No 01
- 4Year ( 2Credit , 3Hour) Mon 1~1 (SCI-AA205) , Wed 1~1 (SCI-AA205)
-
Colloquium of Life Science Research
- Subject No 36337Class No 01
- 3Year ( 3Credit , 3Hour) Mon 3~3 , Wed 2~2
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Bioindustury in the 21st Century
- Subject No 37713Class No 01
- 4Year ( 1Credit , 1Hour) Wed 6~6
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Research for Life ScienceⅠ
- Subject No G16932Class No 01
- Year ( 3Credit , 3Hour)
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Bioinformatics Analysis with Programming
- Subject No G16987Class No 01
- Year ( 3Credit , 3Hour) Tue 4~5 (SCI-C515)
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Academic Background
Cornell University Ph.D.(화학)