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Ewha University

자연과학대학

차선신(車宣信) 교수

화학·나노과학전공

차선신 프로필 사진

				
  • 종합과학관 A동 A412호
  • 02-3277-3858
  • 연구관심분야
    • 단백질 구조와 기능, 구조 기반 단백질 설계 및 생산, 항생제 내성 기작 연구, 신약표적단백질 저해제 개발, 단백질 진화
연구실적
  • A novel splicing variant of DJ-1 in Parkinson's disease induces mitochondrial dysfunction Heliyon, 2023, v.9 no.3, e14039
    SCIE Scopus dColl.
  • An archaeal transcription factor EnfR with a novel ‘eighth note’ fold controls hydrogen production of a hyperthermophilic archaeon Thermococcus onnurineus NA1 Nucleic Acids Research, 2023, v.51 no.18, 10026-10040
    SCIE Scopus dColl.
  • DJ-1 promotes cell migration by interacting with Mena, the mammalian homolog of Drosophila enabled Advances in Biological Regulation, 2023, v.88, 100943
    Scopus dColl.
  • Discovery of a novel NAMPT inhibitor that selectively targets NAPRT-deficient EMT-subtype cancer cells and alleviates chemotherapy-induced peripheral neuropathy THERANOSTICS, 2023, v.13 no.14, 5075-5098
    SCIE Scopus dColl.
  • Heating-mediated purification of active FGF21 and structure-based design of its variant with enhanced potency Scientific Reports, 2023, v.13 no.1, 1005
    SCIE Scopus dColl.
  • Structural and functional characterization of a thermostable secretory phospholipase A2 from Sciscionella marina and its application in liposome biotransformation Acta crystallographica. Section D, Structural biology, 2023, v.79, 188-197
    SCIE Scopus dColl.
  • Targeting BAP1 with small compound inhibitor for colon cancer treatment Scientific Reports, 2023, v.13 no.1, 2264
    SCIE Scopus dColl.
  • Actinopolymorphols E and F, pyrazine alkaloids from a marine sediment-derived bacterium Streptomyces sp JOURNAL OF ANTIBIOTICS, 2022, v.75 no.11, 619-625
    SCIE Scopus dColl.
  • Engineering of a bacterial outer membrane vesicle to a nano-scale reactor for the biodegradation of β-lactam antibiotics Journal of Biotechnology, 2022, v.356, 1-7
    SCIE Scopus dColl.
  • Expression and purification of intracrine human FGF 11 and study of its FGFR-dependent biological activity JOURNAL OF MICROBIOLOGY, 2022, v.60 no.11, 1086-1094
    SCIE Scopus KCI dColl.
  • Folic acid pretreatment and its sustained delivery for chondrogenic differentiation of MSCs Journal of Controlled Release, 2022, v.343, 118-130
    SCIE Scopus dColl.
  • Improvement of FGF7 Thermal Stability by Introduction of Mutations in Close Vicinity to Disulfide Bond and Surface Salt Bridge International Journal of Peptide Research and Therapeutics, 2022, v.28 no.3, 85
    SCIE Scopus dColl.
  • Pralatrexate Sustainably Released from Polypeptide Thermogel Is Effective for Chondrogenic Differentiation of Mesenchymal Stem Cells ACS Applied Materials and Interfaces, 2022, v.14 no.3, 3773-3783
    SCIE Scopus dColl.
  • Saccharobisindole, Neoasterric Methyl Ester, and 7-Chloro-4(1H)-quinolone: Three New Compounds Isolated from the Marine Bacterium Saccharomonospora sp. MARINE DRUGS, 2022, v.20 no.1, 35
    SCIE Scopus dColl.
  • Structural and functional identification of the uncharacterized metallo-β-lactamase superfamily protein TW9814 as a phosphodiesterase with unique metal coordination Acta Crystallographica Section D: Structural Biology, 2022, v.78, 532-541
    SCIE Scopus dColl.
  • The Analyses of Cetacean Virus-Responsive Genes Reveal Evolutionary Marks in Mucosal Immunity-Associated Genes Biochemical Genetics, 2022
    SCIE Scopus dColl.
  • Antibacterial Meroterpenoids, Merochlorins G-J from the Marine Bacterium Streptomyces sp. MARINE DRUGS, 2021, v.19 no.11, 618
    SCIE Scopus dColl.
  • Crystal structure of AmpC BER and molecular docking lead to the discovery of broad inhibition activities of halisulfates against β-lactamases Computational and Structural Biotechnology Journal, 2021, v.19, 145-152
    SCIE Scopus dColl.
  • Dj-1 can replace fgf-2 for long-term culture of human pluripotent stem cells in defined media and feeder-free condition International Journal of Molecular Sciences, 2021, v.22 no.11, 5954
    SCIE Scopus dColl.
  • Gold nanoparticle-assisted SELEX as a visual monitoring platform for the development of small molecule-binding DNA aptasensors Biosensors and Bioelectronics, 2021, v.191, 113468
    SCIE Scopus dColl.
  • Phosphorylation of OGFOD1 by Cell Cycle-Dependent Kinase 7/9 Enhances the Transcriptional Activity of RNA Polymerase II in Breast Cancer Cells CANCERS, 2021, v.13 no.14, 3418
    SCIE Scopus dColl.
  • Spatiotemporal coordination of the RSF1-PLK1-Aurora B cascade establishes mitotic signaling platforms Nature Communications, 2021, v.12 no.1, 5931
    SCIE Scopus dColl.
  • Structural basis of the cooperative activation of type II citrate synthase (HyCS) from Hymenobacter sp. PAMC 26554 INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2021, v.183, 213-221
    SCIE Scopus dColl.
  • Novel inhibition mechanism of carbapenems on the ACC-1 class C β-lactamase Archives of Biochemistry and Biophysics, 2020, v.693, 108570
    SCIE Scopus dColl.
  • Novel short peptide tag from a bacterial toxin for versatile applications JOURNAL OF IMMUNOLOGICAL METHODS, 2020, v.479, UNSP 112750
    SCIE Scopus dColl.
  • Structural and biochemical analyses of an aminoglycoside 2 '-N-acetyltransferase from Mycolicibacterium smegmatis SCIENTIFIC REPORTS, 2020 , 21503
    SCIE Scopus dColl.
  • Complete reconstitution of the diverse pathways of gentamicin B biosynthesis Nature Chemical Biology, 2019, v.15 no.3, 295-303
    SCIE Scopus dColl.
  • Structural Insights into Catalytic Relevances of Substrate Poses in ACC-1 ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2019, v.63 no.11, e01411-19
    SCIE Scopus dColl.
  • Structural basis of small RNA hydrolysis by oligoribonuclease (CpsORN) from Colwellia psychrerythraea strain 34H Scientific Reports, 2019, v.9 no.1, 2649
    SCIE Scopus dColl.
  • Water-Soluble Phthalocyanines Selectively Bind to Albumin Dimers: A Green Approach Toward Enhancing Tumor-Targeted Photodynamic Therapy THERANOSTICS, 2019, v.9 no.22, 6412-6423
    SCIE Scopus dColl.
  • In vitro and in vivo Inhibitory Activity of NADPH Against the AmpC BER Class C beta-Lactamase FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, 2018, v.8, 441
    SCIE Scopus dColl.
  • Inhibitory effect of tartrate against phosphate-induced DJ-1 aggregation INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2018, v.107, 1650-1658
    SCIE Scopus dColl.
  • Structural and Biochemical Characterization of the Curcumin-Reducing Activity of CurA from Vibrio vulnificus JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2018, v.66 no.40, 10608-10616
    SCIE Scopus dColl.
  • Structural basis for the interaction between DJ-1 and Bcl-X-L BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2018, v.495 no.1, 1067-1073
    SCIE Scopus dColl.
  • Analysis of the FGF gene family provides insights into aquatic adaptation in cetaceans SCIENTIFIC REPORTS, 2017, v.7
    SCIE Scopus dColl.
  • Biosynthetic pathways of aminoglycosides and their engineering Current Opinion in Biotechnology, 2017, v.48, 33-41
    SCIE Scopus dColl.
  • Catalytic Intermediate Crystal Structures of Cysteine Desulfurase from the Archaeon Thermococcus onnurineus NA1 ARCHAEA-AN INTERNATIONAL MICROBIOLOGICAL JOURNAL, 2017
    SCIE Scopus dColl.
  • GMP and IMP are competitive inhibitors of CMY-10, an extended-spectrum class C β-lactamase Antimicrobial Agents and Chemotherapy, 2017, v.61 no.5
    SCIE Scopus dColl.
  • Genetic and Structural Characterization of a Thermo-Tolerant, Cold-Active, and Acidic Endo-beta-1,4-glucanase from Antarctic Springtail, Cryptopygus antarcticus JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2017, v.65 no.8, 1630-1640
    SCIE Scopus dColl.
  • Genetic and Structural Characterization of a Thermo-Tolerant, Cold-Active, and Acidic Endo-β-1,4-glucanase from Antarctic Springtail, Cryptopygus antarcticus Journal of Agricultural and Food Chemistry, 2017, v.65 no.8, 1630-1640
    SCIE Scopus dColl.
  • Structural and mechanistic characterization of an archaeal-like chaperonin from a thermophilic bacterium Nature Communications, 2017, v.8 no.1
    SCIE Scopus dColl.
  • Structural and mechanistic insights into the inhibition of class C beta-lactamases through the adenylylation of the nucleophilic serine JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2017, v.72 no.3, 735-743
    SCIE Scopus dColl.
  • Zinc-dependent regulation of zinc import and export genes by Zur NATURE COMMUNICATIONS, 2017, v.8
    SCIE Scopus dColl.
  • Biophysical characterization of the structural change of Nopp140, an intrinsically disordered protein, in the interaction with CK2α Biochemical and Biophysical Research Communications, 2016, v.477 no.2, 181-187
    SCIE Scopus dColl.
  • Cross-protection against Vibrio cholerae infection by monoclonal antibodies against Vibrio vulnificus RtxA1/MARTXVv Microbiology and Immunology, 2016, v.60 no.11, 793-800
    SCIE Scopus dColl.
  • Crystal Structures of Peptide Deformylase from Rice Pathogen Xanthomonas oryzae pv. oryzae in Complex with Substrate Peptides, Actinonin, and Fragment Chemical Compounds JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2016, v.64 no.39, 7307-7314
    SCIE Scopus dColl.
  • Identification of a Highly Conserved Hypothetical Protein TON_0340 as a Probable Manganese-Dependent Phosphatase PLOS ONE, 2016, v.11 no.12
    SCIE Scopus dColl.
  • Purification, crystallization, and preliminary X-ray crystallographic analysis of the Group III chaperonin from Carboxydothermus hydrogenoformans JOURNAL OF MICROBIOLOGY, 2016, v.54 no.6, 440-444
    SCIE Scopus KCI dColl.
  • Structural basis for the extended substrate spectrum of AmpC BER and structure-guided discovery of the inhibition activity of citrate against the class C beta-lactamases AmpC BER and CMY-10 ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, 2016, v.72, 976-985
    SCIE Scopus dColl.
  • Structural basis for the ATP-independent proteolytic activity of LonB proteases and reclassification of their AAA plus modules JOURNAL OF MICROBIOLOGY, 2015, v.53 no.10, 711-717
    SCIE Scopus KCI dColl.
  • The crystal structure of the D-alanine-D-alanine ligase from Acinetobacter baumannii suggests a flexible conformational change in the central domain before nucleotide binding JOURNAL OF MICROBIOLOGY, 2015, v.53 no.11, 776-782
    SCIE Scopus KCI dColl.
  • [학술지논문] Crystal structure of AmpC BER and molecular docking lead to the discovery of broad inhibition activities of halisulfates against beta-lactamases COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL, 2021, v.19 no.0 , 145-152
    SCIE
  • [학술지논문] Structural and biochemical analyses of an aminoglycoside 2 '-N-acetyltransferase from Mycolicibacterium smegmatis SCIENTIFIC REPORTS, 2020, v.10 no.1 , 21503-21503
    SCI
강의
  • 2024-1학기

    • 1학년세미나(자연대)

      • 학수번호 10851분반 09
      • 1학년 ( 1학점 월 7~7
      • 체중 감량 신약 이야기 (비만 치료제)/종A412호
    • 생화학Ⅰ

      • 학수번호 30126분반 01
      • 3학년 ( 3학점 , 3시간) 화 3~3 (종) , 목 2~2 (101)
      • 영어강의
    • 고급화학생물학

      • 학수번호 G15647분반 01
      • 학년 ( 3학점 , 3시간) 수 5~6 (종D108)
      • 시간변경,영어강의
  • 2023-2학기

    • 일반화학Ⅱ

      • 학수번호 20417분반 02
      • 1학년 ( 3학점 , 3시간) 월 5~5 (포453) , 수 4~4 (포453)
      • 영어강의 자연대, 식공1, 화신공1, 환경1, 호크마1, 일반화학과 중복수강 불가
    • 생화학II 강의 계획서 상세보기

      • 학수번호 30127분반 01
      • 3학년 ( 3학점 , 3시간) 월 4~4 (종A) , 목 5~5 (101)
      • 팀티칭
    • 고급생화학

      • 학수번호 G12383분반 01
      • 학년 ( 3학점 , 3시간) 목 3~4 (종D106)
      • 영어강의
  • 2023-1학기

    • 호크마세미나 강의 계획서 상세보기

      • 학수번호 11302분반 18
      • 1학년 ( 1학점 월 7~7 (종A412)
      • 신약 개발의 생화학적 원리
    • 일반화학I

      • 학수번호 20416분반 02
      • 1학년 ( 3학점 , 3시간) 화 5~5 (종A) , 목 6~6 (101)
      • 영어강의,ABEEK 자연대, 화신공1, 식공1, 환경1, 호크마1, 컴공1, 기후·에너지1, 일반화학과 중복수강 불가
    • 생화학I 강의 계획서 상세보기

      • 학수번호 30126분반 01
      • 3학년 ( 3학점 , 3시간) 화 3~3 (종) , 목 2~2 (101)
    • 생화학연구기법

      • 학수번호 G12616분반 01
      • 학년 ( 3학점 , 3시간) 목 2~3 (종D108)
      • 영어강의
  • 2021-2학기

    • 일반화학II

      • 학수번호 20417분반 02
      • 1학년 ( 3학점 , 3시간) 월 2~2 , 목 3~3
      • 영어강의 자연대, 식공1, 화신공1, 환경1, 호크마1, 일반화학과 중복수강 불가
    • 생화학II

      • 학수번호 30127분반 01
      • 3학년 ( 3학점 , 3시간) 화 2~2 , 금 3~3
      • 팀티칭
    • 고급생화학

      • 학수번호 G12383분반 01
      • 학년 ( 3학점 , 3시간) 화 4~5 (종D106)
      • 영어강의
  • 2021-1학기

    • 1학년세미나(자연대)

      • 학수번호 10851분반 07
      • 1학년 ( 1학점 월 7~7 (종A412)
      • 코로나19에 대응하는 신약 개발 전략
    • 일반화학실험I

      • 학수번호 20418분반 04
      • 1학년 ( 1학점 , 1.5시간) 목 6~6 (종)
      • 영어강의 자연대, 호크마1, 다음교시까지 진행
    • 일반화학실험I

      • 학수번호 20418분반 05
      • 1학년 ( 1학점 , 1.5시간) 금 6~6 (종)
      • 영어강의 식공1, 화신공1, 환경1, 호크마1, 다음교시까지 진행
    • 일반화학실험I

      • 학수번호 20418분반 06
      • 1학년 ( 1학점 , 1.5시간) 월 6~6 (종)
      • 영어강의 식공1, 화신공1, 환경1, 호크마1, 다음교시까지 진행
    • 생화학I

      • 학수번호 30126분반 01
      • 3학년 ( 3학점 , 3시간) 화 4~4 , 금 5~5
      • 팀티칭
    • 고급화학생물학

      • 학수번호 G15647분반 01
      • 학년 ( 3학점 , 3시간) 화 5~6 (종D109)
      • 영어강의