오구택(吳九澤) 교수
생명과학과[대학원] /의과대학 /생명과학전공
오구택 교수는 생명과학과 소속 교수로 분자발생유전학 분야 연구의 권위자다. 서울대학교 수의과대학에서 박사학위를 받았으며, 심장과 뇌의 상호작용을 매개하는 면역시스템의 세포 기능과 분자 기전을 규명하여 심뇌혈관질환의 발병 기전 연구를 진행하고 있다. 2012년부터 한국연구재단 리더연구자지원사업(창의적연구)을 수행 후, 이어서 2020년부터 한국연구재단 기초연구사업(리더연구자지원사업) 심장-면역-뇌 세포 네트워크 연구단 단장으로 활동하고 있으며, 현재(2022년)까지 <Immunity>, <Nat Immunol.>, <Circulation>, <Circulation Research>, <Nature Communications.> 등 SCI급 저명 국제학술지에 총 202여편의 논문을 발표했다.
- 종합과학관 C동 305호
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연구실적
- Mitochondrial H2O2 Is a Central Mediator of Diclofenac-Induced Hepatocellular Injury Antioxidants, 2024, v.13 no.1, 17
- N-terminal acetylation of Set1-COMPASS fine-tunes H3K4 methylation patterns Science Advances, 2024, v.10 no.28, adl6280
- Primary Cilium in Neural Crest Cells Crucial for Anterior Segment Development and Corneal Avascularity Investigative ophthalmology & visual science, 2024, v.65 no.3, 30
- Complexation of drug and hapten-conjugated aptamer with universal hapten antibody for pancreatic cancer treatment Journal of Controlled Release, 2023, v.360, 940-952
- Endothelial PTP4A1 mitigates vascular inflammation via USF1/A20 axis-mediated NF-κB inactivation Cardiovascular Research, 2023, v.119 no.5, 1265-1278
- Pancreatic β-cell mitophagy as an adaptive response to metabolic stress and the underlying mechanism that involves lysosomal Ca2+ release Experimental and Molecular Medicine, 2023, v.55 no.9, 1922-1932
- Progerinin, an Inhibitor of Progerin, Alleviates Cardiac Abnormalities in a Model Mouse of Hutchinson–Gilford Progeria Syndrome Cells, 2023, v.12 no.9, 1232
- Unbalanced Redox With Autophagy in Cardiovascular Disease Journal of Lipid and Atherosclerosis, 2023, v.12 no.2, 132-151
- 2′–5′ oligoadenylate synthetase‑like 1 (OASL1) protects against atherosclerosis by maintaining endothelial nitric oxide synthase mRNA stability Nature Communications, 2022, v.13 no.1, 6647
- Peroxiredoxin 2 deletion impairs hippocampal-dependent memory via exacerbating transient ischemia-induced oxidative damage Brain Research Bulletin, 2022, v.184, 99-105
- Peroxiredoxin 3 deficiency induces cardiac hypertrophy and dysfunction by impaired mitochondrial quality control Redox Biology, 2022, v.51, 102275
- Peroxisomal Fitness: A Potential Protective Mechanism of Fenofibrate against High Fat Diet-Induced Non- Alcoholic Fatty Liver Disease in Mice DIABETES & METABOLISM JOURNAL, 2022, v.46 no.6, 829-842
- Peroxisomal Fitness: A Potential Protective Mechanism of Fenofibrate against High Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Mice Diabetes and Metabolism Journal, 2022, v.46 no.6, 829-842
- Plasma Membrane Localization of CD36 Requires Vimentin Phosphorylation; A Mechanism by Which Macrophage Vimentin Promotes Atherosclerosis FRONTIERS IN CARDIOVASCULAR MEDICINE, 2022, v.9, 792717
- Single-cell transcriptomics reveal cellular diversity of aortic valve and the immunomodulation by PPARγ during hyperlipidemia Nature Communications, 2022, v.13 no.1, 5461
- The antioxidant enzyme Peroxiredoxin-1 controls stroke-associated microglia against acute ischemic stroke Redox Biology, 2022, v.54, 102347
- miR-125a-5p attenuates macrophage-mediated vascular dysfunction by targeting Ninjurin1 Cell Death and Differentiation, 2022
- Combined application of rapamycin and atorvastatin improves lipid metabolism in apolipoprotein E-deficient mice with chronic kidney disease BMB REPORTS, 2021, v.54 no.3, 170-175
- ER-associated CTRP1 regulates mitochondrial fission via interaction with DRP1 EXPERIMENTAL AND MOLECULAR MEDICINE, 2021, v.53 no.11, 1769-1780
- Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) AUTOPHAGY, 2021, v.17 no.1, 1-382
- Naa12 compensates for Naa10 in mice in the amino-terminal acetylation pathway ELIFE, 2021, v.10, e65952
- Peroxiredoxins as Potential Targets for Cardiovascular Disease ANTIOXIDANTS, 2021, v.10 no.8, 1244
- The adipokine Retnla deficiency increases responsiveness to cardiac repair through adiponectin-rich bone marrow cells Cell Death and Disease, 2021, v.12 no.4, 307
- Vimentin Deficiency Prevents High-Fat Diet-Induced Obesity and Insulin Resistance in Mice DIABETES & METABOLISM JOURNAL, 2021, v.45 no.1, 97-
- Anti-Inflammatory Actions of Soluble Ninjurin-1 Ameliorate Atherosclerosis Circulation, 2020 , 1736-1751
- Autophagy induction promotes renal cyst growth in polycystic kidney disease EBioMedicine, 2020, v.60, 102986
- CD137 Signaling Regulates Acute Colitis via RALDH2-Expressing CD11b(-)CD103(+) DCs CELL REPORTS, 2020, v.30 no.12, 4124-
- Characterization of human cardiac mesenchymal stromal cells and their extracellular vesicles comparing with human bone marrow derived mesenchymal stem cells BMB REPORTS, 2020, v.53 no.2, 118-123
- Deficiency of peroxiredoxin 2 exacerbates angiotensin II-induced abdominal aortic aneurysm EXPERIMENTAL AND MOLECULAR MEDICINE, 2020, v.52 no.9, 1587-1601
- Extract of high hydrostatic pressure-treated danshen (Salvia miltiorrhiza) ameliorates atherosclerosis via autophagy induction BMB REPORTS, 2020 , 652-657
- Ninjurin1 deficiency aggravates colitis development by promoting M1 macrophage polarization and inducing microbial imbalance FASEB JOURNAL, 2020 , 8702-8720
- Oxidized LDL induces vimentin secretion by macrophages and contributes to atherosclerotic inflammation JOURNAL OF MOLECULAR MEDICINE-JMM, 2020 , 973-983
- SOD1 suppresses pro-inflammatory immune responses by protecting against oxidative stress in colitis Redox Biology, 2020, v.37, 101760
- The Autophagy Regulator p62 Controls PTEN-Dependent Ciliogenesis FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2020, v.8, 465
- The Peroxisome Proliferator-Activated Receptor alpha- Agonist Gemfibrozil Promotes Defense Against Mycobacterium abscessus Infections CELLS, 2020, v.9 no.3, 648
- Current pharmacotherapies for atherosclerotic cardiovascular diseases ARCHIVES OF PHARMACAL RESEARCH, 2019, v.42 no.3, 206-223
- Impaired Peroxisomal Fitness in Obese Mice, a Vicious Cycle Exacerbating Adipocyte Dysfunction via Oxidative Stress ANTIOXIDANTS & REDOX SIGNALING, 2019, v.31 no.18, 1339-1351
- Ninjurin1 positively regulates osteoclast development by enhancing the survival of prefusion osteoclasts EXPERIMENTAL AND MOLECULAR MEDICINE, 2019, v.51, 7
- C1q/TNF-alpha-Related Protein 1 (CTRP1) Maintains Blood Pressure Under Dehydration Conditions CIRCULATION RESEARCH, 2018, v.123 no.5, E5-E19
- Ciliogenesis is reciprocally regulated by PPARA and NR1H4/FXR through controlling autophagy in vitro and in vivo AUTOPHAGY, 2018, v.14 no.6, 1011-1027
- Conventional Dendritic Cells Impair Recovery after Myocardial Infarction JOURNAL OF IMMUNOLOGY, 2018, v.201 no.6, 1784-1798
- Impairment of PPAR alpha and the Fatty Acid Oxidation Pathway Aggravates Renal Fibrosis during Aging JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2018, v.29 no.4, 1223-1237
- LJ-1888, a selective antagonist for the A(3) adenosine receptor, ameliorates the development of atherosclerosis and hypercholesterolemia in apolipoprotein E knock-out mice BMB REPORTS, 2018, v.51 no.10, 520-525
- N-alpha-acetyltransferase 10 (NAA10) in development: the role of NAA10 EXPERIMENTAL AND MOLECULAR MEDICINE, 2018, v.50, 87
- Prdx1 (peroxiredoxin 1) deficiency reduces cholesterol efflux via impaired macrophage lipophagic flux AUTOPHAGY, 2018, v.14 no.1, 120-133
- Transcriptome Analysis Reveals Nonfoamy Rather Than Foamy Plaque Macrophages Are Proinflammatory in Atherosclerotic Murine Models CIRCULATION RESEARCH, 2018, v.123 no.10, 1127-1142
- Decreased thromboembolic stroke but not atherosclerosis or vascular remodelling in mice with ROCK2-deficient platelets CARDIOVASCULAR RESEARCH, 2017, v.113 no.11, 1307-1317
- INO80 haploinsufficiency inhibits colon cancer tumorigenesis via replication stress-induced apoptosis Oncotarget, 2017, v.8 no.70, 115041-115053
- Intragenic CpG islands play important roles in bivalent chromatin assembly of developmental genes PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017, v.114 no.10, E1885-E1894
- Negligible effect of eNOS palmitoylation on fatty acid regulation of contraction in ventricular myocytes from healthy and hypertensive rats PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 2017, v.469 no.9, 1141-1149
- PPAR-alpha Activation Mediates Innate Host Defense through Induction of TFEB and Lipid Catabolism JOURNAL OF IMMUNOLOGY, 2017, v.198 no.8, 3283-3295
- Peroxiredoxin I participates in the protection of reactive oxygen species-mediated cellular senescence BMB Reports, 2017, v.50 no.10, 528-533
- The role of macrophage lipophagy in reverse cholesterol transport Endocrinology and Metabolism, 2017, v.32 no.1, 41-46
- ARD1-mediated Hsp70 acetylation balances stress-induced protein refolding and degradation NATURE COMMUNICATIONS, 2016, v.7
- Disruption of Ninjurin1 Leads to Repetitive and Anxiety-Like Behaviors in Mice Molecular Neurobiology, 2016, v.54 no.9, 1-16
- INCREASED MITOCHONDRIAL ROS ACCELERATE ATHEROSCLEROSIS IN MITOCHONDRIAL CATALYTIC ENZYME 3 DEFICIENT MICE ATHEROSCLEROSIS, 2016, v.252, E220-E220
- Indoleamine 2,3-Dioxygenase-Expressing Aortic Plasmacytoid Dendritic Cells Protect against Atherosclerosis by Induction of Regulatory T Cells Cell Metabolism, 2016, v.23 no.5, 852-866
- KCa3.1 upregulation preserves endothelium-dependent vasorelaxation during aging and oxidative stress Aging Cell, 2016, v.15 no.5
- Metformin stimulates IGFBP-2 gene expression through PPARalpha in diabetic states SCIENTIFIC REPORTS, 2016, v.6
- Ninjurin1 inhibits colitis-mediated colon cancer development and growth by suppression of macrophage infiltration through repression of FAK signaling ONCOTARGET, 2016, v.7 no.20, 29592-29604
- PEROXIREDOXIN 1 HAVE PROTECTIVE ROLE IN THE VASCULAR DISEASE BY REGULATING MACROPHAGES ATHEROSCLEROSIS, 2016, v.252, E226-E226
- PEROXIREDOXIN1 PROTECTS MACROPHAGES FROM IMPAIRED LIPOPHAGIC FLUX BY OXIDATIVE STRESS IN ATHEROSCLEROSIS CARDIOLOGY, 2016, v.134, 398-398
- Role of muscular eNOS in skeletal arteries: endothelium-independent hypoxic vasoconstriction of the femoral artery is impaired in eNOS-deficient mice AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2016, v.311 no.3, C508-C517
- Sirt6 cooperates with Blimp1 to positively regulate osteoclast differentiation Scientific Reports, 2016, v.6
- The Roles of CD137 Signaling in Atherosclerosis KOREAN CIRCULATION JOURNAL, 2016, v.46 no.6, 753-761
- 토끼에서 ACAT 억제에 의한 3,4-다이하이드록시 하이드로시나믹산의 동맥경화 완화 효과 대한임상검사과학회지, 2016, v.48 no.4, 280
- Extract of Rhus verniciflua stokes protects the diet-induced hyperlipidemia in mice Archives of Pharmacal Research, 2015, v.38 no.11, 2049-2058
- Regulation of IGFBP-2 expression during fasting BIOCHEMICAL JOURNAL, 2015, v.467, 453-460
- Arrest defective 1 regulates the oxidative stress response in human cells and mice by acetylating methionine sulfoxide reductase A Cell Death and Disease, 2014, v.5 no.10
- CD137-inducing factors from T cells and macrophages accelerate the destabilization of atherosclerotic plaques in hyperlipidemic mice FASEB JOURNAL, 2014, v.28 no.11, 4779-4791
- Developmental endothelial locus-1 inhibits MIF production through suppression of NF-kappa B in macrophages INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2014, v.33 no.4, 919-924
- Hypoxia-Induced Endothelial Progenitor Cell Function Is Blunted in Angiotensinogen Knockout Mice MOLECULES AND CELLS, 2014, v.37 no.6, 487-496
- Inhibition of Ninjurin 1 restores erectile function through dual angiogenic and neurotrophic effects in the diabetic mouse PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2014, v.111 no.26, E2731-E2740
- NAA10 controls osteoblast differentiation and bone formation as a feedback regulator of Runx2 NATURE COMMUNICATIONS, 2014, v.5
- Ninjurin1 Deficiency Attenuates Susceptibility of Experimental Autoimmune Encephalomyelitis in Mice JOURNAL OF BIOLOGICAL CHEMISTRY, 2014, v.289 no.6, 3328-3338
- Ninjurin1 enhances the basal motility and transendothelial migration of immune cells by inducing protrusive membrane dynamics Journal of Biological Chemistry, 2014, v.289 no.32, 21926-21936
- Reactive Oxygen Species Play a Critical Role in Collagen-Induced Platelet Activation via SHP-2 Oxidation ANTIOXIDANTS & REDOX SIGNALING, 2014, v.20 no.16, 2528-2540
- Retnla Overexpression Attenuates Allergic Inflammation of the Airway PLOS ONE, 2014, v.9 no.11
- The adipokine Retnla modulates cholesterol homeostasis in hyperlipidemic mice Nature Communications, 2014, v.5, Article number:4410
- Tripartite Motif-Containing Protein 30 Modulates TCR-Activated Proliferation and Effector Functions in CD4(+) T Cells PLOS ONE, 2014, v.9 no.4, Article ID e95805
- Two distinct domains of Flo8 activator mediates its role in transcriptional activation and the physical interaction with Mss11 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2014, v.449 no.2, 202-207
강의
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2024-2학기
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분자의생물학
- 학수번호 36336분반 01
- 4학년 ( 3학점 , 3시간) 월 4~4 (종A) , 목 5~5 (102)
- 팀티칭
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동물생리학Ⅱ
- 학수번호 38209분반 01
- 2학년 ( 3학점 , 3시간) 화 2~2 (포366) , 금 3~3 (포366)
- 팀티칭
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발생유전학특론Ⅱ
- 학수번호 G16955분반 01
- 학년 ( 3학점 , 3시간) 월 5~6 (종C)
- 영어강의
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2024-1학기
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발생생물학
- 학수번호 20598분반 01
- 3학년 ( 3학점 , 3시간) 수 6~6 (포365) , 금 4~4 (포365)
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발생유전학특론Ⅰ
- 학수번호 G16954분반 01
- 학년 ( 3학점 , 3시간) 수 2~3 (종C418)
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2023-2학기
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분자의생물학 강의 계획서 상세보기
- 학수번호 36336분반 01
- 4학년 ( 3학점 , 3시간) 월 4~4 (종A) , 목 5~5 (102)
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동물생리학II 강의 계획서 상세보기
- 학수번호 38209분반 01
- 2학년 ( 3학점 , 3시간) 화 2~2 (포366) , 금 3~3 (포366)
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발생유전학Ⅱ
- 학수번호 G17001분반 01
- 학년 ( 3학점 , 3시간) 월 5~6 (종C)
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2023-1학기
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생명의신비 강의 계획서 상세보기
- 학수번호 10066분반 01
- 학년 ( 3학점 , 3시간) 월 3~3 , 목 4~4
- 원격강의 생명과학전공 수강 불가
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발생생물학 강의 계획서 상세보기
- 학수번호 20598분반 01
- 3학년 ( 3학점 , 3시간) 수 6~6 (포365) , 금 4~4 (포365)
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발생유전학Ⅰ
- 학수번호 G16980분반 01
- 학년 ( 3학점 , 3시간) 수 2~3 (종C)
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2021-2학기
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분자의생물학
- 학수번호 36336분반 01
- 4학년 ( 3학점 , 3시간) 화 5~5 , 목 6~6
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동물생리학II
- 학수번호 38209분반 01
- 2학년 ( 3학점 , 3시간) 월 3~3 (포452) , 수 2~2 (포452)
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발생유전학특론Ⅱ
- 학수번호 G16955분반 01
- 학년 ( 3학점 , 3시간) 월 5~6 (종C)
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2021-1학기
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1학년세미나(자연대)
- 학수번호 10851분반 12
- 1학년 ( 1학점 월 7~7 (종C303)
- 뇌․심혈관질환의 생명과학적 원인 규명 및 치료
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발생생물학
- 학수번호 20598분반 01
- 3학년 ( 3학점 , 3시간) 화 5~5 , 목 6~6
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생명과학실험III
- 학수번호 35313분반 01
- 3학년 ( 2학점 , 3시간) 화 6~7 (종A205)
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생명과학실험III
- 학수번호 35313분반 02
- 3학년 ( 2학점 , 3시간) 목 6~7 (종A205)
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발생유전학특론Ⅰ
- 학수번호 G16954분반 01
- 학년 ( 3학점 , 3시간) 수 2~3
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학력
서울대학교 수의학박사(수의학)