연구실적

• Nox4-SH3YL1 complex is involved in diabetic nephropathy iScience, 2024, v.27 no.2, 108868
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• Phospholipase C-β3 is dispensable for vascular constriction but indispensable for vascular hyperplasia Experimental and Molecular Medicine, 2024, v.56 no.7, 1620-1630
  SCIE Scopus KCI dColl.
• Ahnak is required to balance calcium ion homeostasis and smooth muscle development in the urinary system Cell and Bioscience, 2023, v.13 no.1, 108
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• CYLD destabilizes NoxO1 protein by promoting ubiquitination and regulates prostate cancer progression Cancer Letters, 2022, v.525, 146-157
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• Discovery of a NADPH oxidase inhibitor, (E)-3-cyclohexyl-5-(4-((2-hydroxyethyl)(methyl)amino)benzylidene)-1-methyl-2-thioxoimidazolidin-4-oneone, as a novel therapeutic for Parkinson's disease European Journal of Medicinal Chemistry, 2022, v.244, 114854
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• NADPH oxidase inhibitor development for diabetic nephropathy through water tank model Kidney Research and Clinical Practice, 2022, v.41, S89-S98
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• Nox4-IGF2 Axis Promotes Differentiation of Embryoid Body Cells Into Derivatives of the Three Embryonic Germ Layers Stem Cell Reviews and Reports, 2022, v.18 no.3, 1181-1192
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• Ahnak deficiency attenuates high-fat diet-induced fatty liver in mice through FGF21 induction EXPERIMENTAL AND MOLECULAR MEDICINE, 2021, v.53 no.3, 468-482
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• Proprotein convertase subtilisin/kexin Type 9 is required for Ahnak-mediated metastasis of melanoma into lung epithelial cells NEOPLASIA, 2021, v.23 no.9, 993-1001
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• Sesquiterpene Alcohol Cedrol Chemosensitizes Human Cancer Cells and Suppresses Cell Proliferation by Destabilizing Plasma Membrane Lipid Rafts Frontiers in Cell and Developmental Biology, 2021 , 571676
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• Structural Requirements of 1-(2-Pyridinyl)-5-pyrazolones for Disproportionation of Boronic Acids MOLECULES, 2021, v.26 no.22, 6814
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• APX-115, a pan-NADPH oxidase inhibitor, protects development of diabetic nephropathy in podocyte specific NOX5 transgenic mice FREE RADICAL BIOLOGY AND MEDICINE, 2020, v.161, 92-101
  SCIE Scopus dColl.
• Crystal structure determination of N- and O-alkylated tautomers of 1-(2-pyridinyl)-5-hydroxypyrazole Journal of Molecular Structure, 2020, v.1215, 128272
  SCIE Scopus dColl.
• Function of NADPH Oxidases in Diabetic Nephropathy and Development of Nox Inhibitors BIOMOLECULES & THERAPEUTICS, 2020, v.28 no.1, 25-33
  SCIE Scopus KCI dColl.
• Intensive morphometric analysis of enormous alterations in skeletal bone system with micro-CT for AHNAK−/− mice Anatomical Science International, 2020, v.95 no.3, 323-333
  SCIE Scopus dColl.
• LPS-Induced Acute Kidney Injury Is Mediated by Nox4-SH3YL1 Cell Reports, 2020, v.33 no.3, 108245
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• 2-(trimethylammonium)ethyl (R)-3-methoxy-3-oxo-2-stearamidopropyl phosphate enhances thrombopoietin-induced megakaryocytic differentiation and plateletogenesis BMB REPORTS, 2019, v.52 no.7, 434-438
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• Novel crosstalk between Vps26a and Nox4 signaling during neurogenesis Cell Death and Differentiation, 2019, v.26 no.9, 1582-1599
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• Oxidative activation of type III CD38 by NADPH oxidase-derived hydrogen peroxide in Ca2+ signaling FASEB JOURNAL, 2019, v.33 no.3, 3404-3419
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• Pharmacokinetic Study of NADPH Oxidase Inhibitor Ewha-18278, a Pyrazole Derivative PHARMACEUTICS, 2019, v.11 no.9, 482
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• The flagellin-TLR5-Nox4 axis promotes the migration of smooth muscle cells in atherosclerosis Experimental and Molecular Medicine, 2019, v.51 no.7, 78
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• A pan-NADPH Oxidase Inhibitor Ameliorates Kidney Injury in Type 1 Diabetic Rats PHARMACOLOGY, 2018, v.102 no.3-4, 180-189
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• AHNAK loss in mice promotes type II pneumocyte hyperplasia and lung tumor development Molecular Cancer Research, 2018, v.16 no.8, 1287-1298
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• Ahnak promotes tumor metastasis through transforming growth factor-β-mediated epithelial-mesenchymal transition Scientific Reports, 2018, v.8 no.1, 14379
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• Fc gamma R/ROS/CK2 alpha Is the Key Inducer of NF-kappa B Activation in a Murine Model of Asthma INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 2018, v.175 no.1-2, 16-25
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• Inhibition of Neuroinflammation by AIBP: Spinal Effects upon Facilitated Pain States CELL REPORTS, 2018, v.23 no.9, 2667-2677
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• A novel pan-Nox inhibitor, APX-115, protects kidney injury in streptozotocin-induced diabetic mice: Possible role of peroxisomal and mitochondrial biogenesis Oncotarget, 2017, v.8 no.43, 74217-74232
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• APX-115, a first-in-class pan-NADPH oxidase (Nox) inhibitor, protects db/db mice from renal injury LABORATORY INVESTIGATION, 2017, v.97 no.4, 419-431
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• C-terminal tail of NADPH oxidase organizer 1 (Noxo1) mediates interaction with NADPH oxidase activator (Noxal) in the NOX1 complex BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2017, v.490 no.3, 594-600
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• Fluorescence-reported allelic exchange mutagenesis reveals a role for Chlamydia trachomatis TmeA in invasion that is independent of host AHNAK Infection and Immunity, 2017, v.85 no.12, e00640-17
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• NADPH oxidase 4 is required for the generation of macrophage migration inhibitory factor and host defense against Toxoplasma gondii infection Scientific Reports, 2017, v.7 no.1
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• A novel pyrazole derivative protects from ovariectomy-induced osteoporosis through the inhibition of NADPH oxidase Scientific Reports, 2016, v.6
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• AHNAK deficiency promotes browning and lipolysis in mice via increased responsiveness to beta-adrenergic signalling SCIENTIFIC REPORTS, 2016, v.6
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• Ahnak stimulates BMP2-mediated adipocyte differentiation through Smad1 activation Obesity, 2016, 6 JAN 2016
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• Flagellin-induced NADPH oxidase 4 activation is involved in atherosclerosis Scientific Reports, 2016, v.6
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• Glutamine Prevents Late-Phase Anaphylaxis via MAPK Phosphatase 1-Dependent Cytosolic Phospholipase A(2) Deactivation INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 2016, v.171 no.1, 61-70
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• NADPH Oxidase 1 Activity and ROS Generation Are Regulated by Grb2/Cbl-Mediated Proteasomal Degradation of NoxO1 in Colon Cancer Cells CANCER RESEARCH, 2016, v.76 no.4
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• Regulation of c-Myc expression by Ahnak promotes induced pluripotent stem cell generation Journal of Biological Chemistry, 2016, v.291 no.2, 752-761
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• Synthesis and biological evaluation of 3-substituted 5-benzylidene-1-methyl-2-thiohydantoins as potent NADPH oxidase (NOX) inhibitors BIOORGANIC & MEDICINAL CHEMISTRY, 2016, v.24 no.18, 4144-4151
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• 2-(Trimethylammonium)ethyl (R)-3-methoxy-3-oxo-2-stearamidopropyl phosphate promotes megakaryocytic differentiation of myeloid leukaemia cells and primary human CD34+ haematopoietic stem cells Journal of Tissue Engineering and Regenerative Medicine, 2015, v.9 no.4, 435-446
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• Dual oxidase 2 is essential for house dust mite-induced pro-inflammatory cytokine production in human keratinocytes Experimental Dermatology, 2015, 21 Aug 2015
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• Obesity Resistance and Enhanced Insulin Sensitivity in Ahnak(-/-) Mice Fed a High Fat Diet Are Related to Impaired Adipogenesis and Increased Energy Expenditure PLOS ONE, 2015, v.10 no.10
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• Phytosphingosine promotes megakaryocytic differentiation of myeloid leukemia cells BMB Reports, 2015, v.48 no.12, 691-695
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• 2-(Trimethylammonium) Ethyl (R)-3-Methoxy-3-oxo-2-Stearamidopropyl Phosphate Suppresses Osteoclast Maturation and Bone Resorption by Targeting Macrophage-Colony Stimulating Factor Signaling MOLECULES AND CELLS, 2014, v.37 no.8, 628-635
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• Ahnak functions as a tumor suppressor via modulation of TGF beta/Smad signaling pathway ONCOGENE, 2014, v.33 no.38, 4675-4684
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• Ahnak functions as a tumor suppressor via modulation of TGFβ/Smad signaling pathway. Oncogene, 2014, v.33 no.38, 4675-4684
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• Dual Oxidase 2 in Lung Epithelia Is Essential for Hyperoxia-Induced Acute Lung Injury in Mice ANTIOXIDANTS & REDOX SIGNALING, 2014, v.21 no.13, 1803-1818
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• Hydrogen peroxide generated by DUOX1 regulates the expression levels of specific differentiation markers in normal human keratinocytes JOURNAL OF DERMATOLOGICAL SCIENCE, 2014, v.74 no.1, 56-63
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• Nox4-Mediated Cell Signaling Regulates Differentiation and Survival of Neural Crest Stem Cells MOLECULES AND CELLS, 2014, v.37 no.12, 907-911
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• Testosterone Stimulates Duox1 Activity through GPRC6A in Skin Keratinocytes JOURNAL OF BIOLOGICAL CHEMISTRY, 2014, v.289 no.42, 28835-28845
  SCIE Scopus dColl.
• [학술지논문] APX-115, a pan-NADPH oxidase inhibitor, protects development of diabetic nephropathy in podocyte specific NOX5 transgenic mice FREE RADICAL BIOLOGY AND MEDICINE, 2020, v.161 no.0 , 92-101
  SCI
• [학술지논문] Crystal structure determination of N- and O-alkylated tautomers of 1-(2-pyridinyl)-5-hydroxypyrazole JOURNAL OF MOLECULAR STRUCTURE, 2020, v.1215 no.0 , 128272-128272
  SCI
• [학술지논문] Function of NADPH Oxidases in Diabetic Nephropathy and Development of Nox Inhibitors BIOMOLECULES & THERAPEUTICS, 2020, v.28 no.1 , 25-33
  SCIE
• [학술지논문] Intensive morphometric analysis of enormous alterations in skeletal bone system with micro-CT for AHNAK(-/-) mice ANATOMICAL SCIENCE INTERNATIONAL, 2020, v.95 no.3 , 323-333
  SCIE
• [학술지논문] LPS-Induced Acute Kidney Injury Is Mediated by Nox4-SH3YL1 CELL REPORTS, 2020, v.33 no.3 , 108245-108245
  SCIE

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